Skip to Content

Librium Side Effects

Generic Name: chlordiazepoxide

Note: This document contains side effect information about chlordiazepoxide. Some of the dosage forms listed on this page may not apply to the brand name Librium.

For the Consumer

Applies to chlordiazepoxide: oral capsule, oral tablet

Along with its needed effects, chlordiazepoxide (the active ingredient contained in Librium) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlordiazepoxide:

Rare
  • Fainting
  • mood or mental changes
  • shakiness and unsteady walk
  • unsteadiness, trembling, or other problems with muscle control or coordination
Incidence not known
  • Abdominal and muscle cramps
  • chills
  • clay-colored stools
  • convulsions
  • cough or hoarseness
  • dark urine
  • difficulty in speaking
  • dizziness
  • drooling
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching
  • light-colored stools
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea and vomiting
  • painful or difficult urination
  • pale skin
  • rash
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • shuffling walk
  • sleeplessness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • stomach pain
  • sweating
  • swelling
  • trouble sleeping
  • twisting movements of the body
  • unable to sleep
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking chlordiazepoxide:

Symptoms of overdose
  • Change in consciousness
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Some side effects of chlordiazepoxide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • inability to have or keep an erection
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • loss in sexual ability, desire, drive, or performance
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide: injectable powder for injection, oral capsule, oral tablet

General

The most commonly reported side effects were light-headedness, drowsiness, sedation, unsteadiness, and ataxia.[Ref]

Nervous system

Common (1% to 10%): Ataxia, balance disorder, confusional state, dizziness, sedation, somnolence, unsteadiness
Rare (less than 0.1%): Headache, reduced alertness, vertigo
Frequency not reported: Amnesia, anterograde amnesia, changes in EEG patterns, confusion, depressed level of consciousness, dysarthria, dyskinesia, extrapyramidal symptoms, gait disturbance, syncope, tremor[Ref]

Other

Common (1% to 10%): Fatigue
Frequency not reported: Falls, paradoxical drug reaction, rebound phenomena[Ref]

Hematologic

Rare (0.01% to 0.1%): Agranulocytosis, bone marrow depression, leukopenia, pancytopenia, thrombocytopenia
Frequency not reported: Blood dyscrasias[Ref]

Genitourinary

Rare (less than 0.1%): Erectile dysfunction, incontinence, menstrual disorder, urinary retention
Frequency not reported: Minor menstrual irregularities[Ref]

Ocular

Rare (less than 0.1%): Blurred vision, diplopia, visual disturbance[Ref]

Psychiatric

Rare (less than 0.1%): Libido disorders, numbed emotions
Frequency not reported: Abnormal behavior, aggression, aggressive outbursts, agitation, anxiety, delusion, dependence, depression, drug abuse, emotional disturbances, hallucinations, inappropriate behavior, increased/decreased libido, insomnia, irritability, nightmares, physical dependence, psychological dependence, psychosis, psychotic disorder, rage, restlessness, sleep disorders, suicidal ideation, suicide attempt, withdrawal[Ref]

Dermatologic

Rare (less than 0.1%): Rash, skin reactions
Frequency not reported: skin eruptions[Ref]

Gastrointestinal

Rare (less than 0.1%): Gastrointestinal symptoms/upset
Frequency not reported: Constipation, nausea, salivation altered/changes[Ref]

Cardiovascular

Rare (less than 0.1%): Hypotension
Frequency not reported: Edema[Ref]

Hypersensitivity

Very rare (less than 0.01%): Angioedema, anaphylactic reaction
Frequency not reported: Hypersensitivity[Ref]

Hepatic

Frequency not reported: Blood bilirubin increased, hepatic dysfunction, jaundice, transaminases increased[Ref]

Metabolic

Frequency not reported: Blood alkaline phosphatase increased, increased appetite[Ref]

Musculoskeletal

Frequency not reported: Fractures, muscle weakness[Ref]

Respiratory

Frequency not reported: Respiratory depression[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.

Some side effects of Librium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide