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Librium Side Effects

Generic Name: chlordiazepoxide

Note: This page contains information about the side effects of chlordiazepoxide. Some of the dosage forms included on this document may not apply to the brand name Librium.

For the Consumer

Applies to chlordiazepoxide: oral capsule, oral tablet

In addition to its needed effects, some unwanted effects may be caused by chlordiazepoxide (the active ingredient contained in Librium). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking chlordiazepoxide:

  • Fainting
  • mood or mental changes
  • shakiness and unsteady walk
  • unsteadiness, trembling, or other problems with muscle control or coordination
Incidence not known:
  • Abdominal and muscle cramps
  • chills
  • clay-colored stools
  • convulsions
  • cough or hoarseness
  • dark urine
  • difficulty in speaking
  • dizziness
  • drooling
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching
  • light-colored stools
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea and vomiting
  • painful or difficult urination
  • pale skin
  • rash
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • shuffling walk
  • sleeplessness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • stomach pain
  • sweating
  • swelling
  • trouble sleeping
  • twisting movements of the body
  • unable to sleep
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking chlordiazepoxide, get emergency help immediately:

Symptoms of overdose:
  • Change in consciousness
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Minor Side Effects

Some of the side effects that can occur with chlordiazepoxide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • inability to have or keep an erection
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • loss in sexual ability, desire, drive, or performance
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide: injectable powder for injection, oral capsule, oral tablet

Nervous system

Common (1% to 10%): Light-headedness, drowsiness, sedation, unsteadiness, ataxia
Rare (less than 0.1%): Reduced alertness, headache, dizziness, vertigo
Frequency not reported: Confusion, extrapyramidal symptoms, changes in EEG patterns, restlessness, agitation, tremor, dysarthria, amnesia[Ref]


Rare (less than 0.1%): Fatigue
Frequency not reported: Edema[Ref]


Rare (less than 0.1%): Numbed emotions
Frequency not reported: Dependence, irritability, aggressive outbursts, delusion, nightmares, hallucinations, inappropriate behavior, rage, psychosis[Ref]


Frequency not reported: Blood dyscrasias (including agranulocytosis), thrombocytopenia[Ref]


Frequency not reported: Jaundice, hepatic dysfunction[Ref]


Frequency not reported: Skin eruptions[Ref]


Rare (less than 0.1%): Hypotension[Ref]


Rare (less than 0.1%): Gastrointestinal symptoms
Frequency not reported: Nausea, constipation, salivation changes[Ref]


The most commonly reported side effects were light-headedness, drowsiness, sedation, unsteadiness, and ataxia.[Ref]


Rare (less than 0.1%): Changes in libido, urinary retention
Frequency not reported: Minor menstrual irregularities, increased/decreased libido, incontinence[Ref]


Rare (less than 0.1%): Muscle weakness[Ref]


Rare (less than 0.1%): Blurred vision, visual disturbance[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.

Not all side effects for Librium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.