Levoleucovorin Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 5, 2025.

Applies to levoleucovorin: intravenous powder for solution, intravenous solution.

Serious side effects of levoleucovorin

Along with its needed effects, levoleucovorin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking levoleucovorin:

More common side effects

• cloudy urine
• decrease in urine output or decrease in urine-concentrating ability
• difficult or labored breathing
• fever
• general feeling of discomfort or illness
• lack or loss of strength
• shortness of breath
• stomach cramps, tenderness, or pain
• tightness in the chest
• unusual tiredness or weakness
• watery or bloody diarrhea
• wheezing

Incidence not known

• feeling unusually cold
• shivering

Other side effects of levoleucovorin

Some side effects of levoleucovorin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• bad, unusual, or unpleasant (after) taste
• belching
• blistering, crusting, irritation, itching, reddening, or swelling of the skin
• burning, tingling, numbness, or pain in the hands, arms, feet, or legs
• change in taste
• cracked, dry, or scaly skin
• decreased appetite
• diarrhea
• hair loss or thinning of the hair
• heartburn
• indigestion
• loss of appetite
• mood or mental changes
• nausea
• sensation of pins and needles
• stabbing pain
• stomach discomfort or upset
• swelling or inflammation of the mouth
• vomiting
• weight loss

Incidence not known

• rash

For healthcare professionals

Applies to levoleucovorin: intravenous powder for injection, intravenous solution.

Gastrointestinal adverse events

• Very common (10% or more): Stomatitis (37.5%), vomiting (37.5%), nausea (18.8%)
• Common (1% to 10%): Diarrhea, dyspepsia, typhlitis^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea^[Ref]

Dermatologic

• Common (1% to 10%): Dermatitis
• Postmarketing reports: Pruritus, rash^[Ref]

Other

• Postmarketing reports: Temperature change, rigors^[Ref]

Nervous system

• Common (1% to 10%): Neuropathy, taste perversion^[Ref]

Renal

• Common (1% to 10%): Renal function abnormal^[Ref]

Hypersensitivity

• Postmarketing reports: Possible allergic reactions

Hematologic

• Frequency not reported: Leukopenia, thrombocytopenia

Psychiatric

• Common (1% to 10%): Confusion

Further information

Levoleucovorin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer