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Adrucil (injection)

Generic name: fluorouracil (injection) [ FLOOR-oh-URE-a-sil ]
Drug class: Antimetabolites

Medically reviewed by on Nov 23, 2022. Written by Cerner Multum.

What is Adrucil?

Adrucil is used to treat cancer of the colon, rectum, breast, stomach, or pancreas.

Adrucil is often given in combination chemotherapy with other cancer drugs.

Adrucil may also be used for purposes not listed in this medication guide.


Before using Adrucil tell your doctor about all your medical conditions or allergies, all medicines you use, and if you are pregnant or breastfeeding.

Before taking this medicine

Tell your doctor if you have ever had:

  • a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency;

  • heart problems; or

  • bone marrow depression.

Both men and women using Adrucil should use effective birth control to prevent pregnancy. Adrucil can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Adrucil.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Adrucil can harm an unborn baby.

You should not breastfeed while using this medicine.

How is Adrucil given?

Adrucil is given as an infusion into a vein. A healthcare provider will give you this injection.

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Adrucil is often given in a treatment cycle, and you may need to use the medicine only on certain days of each cycle. This medicine is sometimes given in a continuous infusion over 24 to 46 hours.

How often you need Adrucils will depend on many factors, including side effects and how your body responds to the medicine. Your doctor will determine how long to treat you with this medicine.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Adrucil is injected.

Adrucil can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Adrucil.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Adrucil?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Adrucil side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Adrucil may cause serious side effects. Call your doctor at once if you have:

  • fever (take your temperature each day while receiving Adrucil);

  • severe or ongoing diarrhea;

  • vision problems;

  • confusion, problems with balance or muscle movement;

  • painful mouth sores, red or swollen gums, trouble swallowing, talking, or eating;

  • bone marrow suppression--dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;

  • "hand and foot syndrome"--pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;

  • heart problems--chest pain or pressure, pain spreading to your jaw or shoulder, irregular heartbeats, nausea, sweating, feeling dizzy or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Adrucil may include:

  • diarrhea;

  • mouth sores;

  • heart problems; or

  • bone marrow suppression.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adrucil?

If you take a blood thinner (warfarin, Coumadin, Jantoven), you may need to have more frequent "INR" or prothrombin time tests.

Other drugs may affect Adrucil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.