LetibotulinumtoxinA Side Effects

Applies to letibotulinumtoxinA: intramuscular powder for injection.

General adverse events

The most common adverse reaction occurring in more than 2% of patients was headache. Adverse reactions may occur within the first few days following injection and may have a transient duration of up to several months or longer.^[Ref]

Dermatologic

• Rare (0.01% to 0.1%): Brow ptosis/heaviness, dry skin, urticaria, folliculitis

Gastrointestinal

• Rare (0.01% to 0.1%): Constipation, nausea, oral herpes
• Frequency not reported: Dysphagia^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Anti-drug antibodies

Local

• Common (1% to 10%): Injection site reaction
• Uncommon (0.1% to 1%): Injection site: Pain, pressure, bruising, swelling, pruritus, mass
• Rare (0.01% to 0.1%): Folliculitis, periorbital hematoma, contusion
• Frequency not reported: Injection site: Nodule, inflammation, tenderness, erythema, itching, bleeding^[Ref]

Metabolic

• Rare (0.01% to 0.1%): Increased serum potassium^[Ref]

Musculoskeletal

• Frequency not reported: Local muscle weakness (expected due to pharmacological action of botulinum toxin in muscle tissue)^[Ref]

Ocular

• Uncommon (0.1% to 1%): Eyelid ptosis, blepharospasm, periorbital edema
• Rare (0.01% to 0.1%): Conjunctival hemorrhage, dry eye, eye pain^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, bronchitis
• Rare (0.01% to 0.1%): Pharyngeal hypoesthesia, streptococcal pharyngitis, pneumonia, sinusitis^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Head discomfort
• Rare (0.01% to 0.1%): Migraine, dizziness, paresthesia, visual field defect
• Frequency not reported: Procedural headache^[Ref]

See also:

Frequently asked questions

• What is botulinum toxin used to treat?

Further information

LetibotulinumtoxinA side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer