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Kineret Side Effects

Generic Name: anakinra

Note: This page contains information about the side effects of anakinra. Some of the dosage forms included on this document may not apply to the brand name Kineret.

In Summary

Common side effects of Kineret include: infection, antibody development, and inflammation at injection site. Other side effects include: neutropenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to anakinra: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by anakinra (the active ingredient contained in Kineret). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking anakinra:

More common:
  • Diarrhea
  • fever or chills
  • headache
  • itching, pain, redness, swelling, tenderness or warmth on the skin
  • joint pain
  • muscle aches and pains
  • nausea or vomiting
  • runny nose or sneezing
  • sore throat
Less common or rare:
  • Difficulty with swallowing
  • hives, itching, or rash
  • swelling of the face or lips
  • unusual bruising or bleeding
  • unusual tiredness or weakness
Incidence not known:
  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

Minor Side Effects

Some of the side effects that can occur with anakinra may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty with moving
  • headache
  • muscle aches or stiffness

For Healthcare Professionals

Applies to anakinra: subcutaneous solution


The most serious side effects have included infections and neutropenia, while the most common side effects have included injection site reactions.[Ref]


Very common (10% or more): Injection site reaction (71%) (including erythema, ecchymosis, inflammation, and pain)[Ref]


Common (1% to 10%): Neutropenia, decreased total white blood cell count, decreased platelets
Frequency not reported: small increases in the eosinophil differential percentage[Ref]


Very common (10% or more): Vomiting (14%)
Common (1% to 10%): Nausea, diarrhea, abdominal pain[Ref]


Very common (10% or more): Upper respiratory tract infection (19%), nasopharyngitis (11%)
Common (1% to 10%): Sinusitis, bronchitis[Ref]

Nervous system

Very common (10% or more): Headache (12%)[Ref]


Common (1% to 10%): Arthralgia[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Very common (10% or more): Worsening of RA (19%), pyrexia (11%)[Ref]


Uncommon (0.1% to 1%): Hepatic enzyme increased
Frequency not reported: Non-infectious hepatitis, elevations of transaminases[Ref]


Uncommon (0.1% to 1%): Allergic reactions (including anaphylactic reactions), angioedema, urticaria, pruritus
Frequency not reported: Rash[Ref]


Common (1% to 10%): Serious infections (primarily bacterial) (e.g., cellulitis, pneumonia, bone and joint infections), influenza-like symptoms
Frequency not reported: Development of immunogenicity[Ref]


Frequency not reported: Increased rate of lymphoma[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL:" ([2006]):

3. "Product Information. Kineret (anakinra)." Amgen, Thousand Oaks, CA.

Not all side effects for Kineret may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.