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Isordil Tembids Side Effects

Generic name: isosorbide dinitrate

Medically reviewed by Last updated on Mar 29, 2024.

Note: This document contains side effect information about isosorbide dinitrate. Some dosage forms listed on this page may not apply to the brand name Isordil Tembids.

Applies to isosorbide dinitrate: capsule extended release, tablet, tablet extended release.

Serious side effects of Isordil Tembids

Along with its needed effects, isosorbide dinitrate (the active ingredient contained in Isordil Tembids) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking isosorbide dinitrate:


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking isosorbide dinitrate:

Symptoms of overdose

For Healthcare Professionals

Applies to isosorbide dinitrate: oral capsule extended release, oral tablet, oral tablet chewable, oral tablet extended release, sublingual tablet.


The most common side effect was headache.[Ref]

Nervous system

Frequency not reported: Headache, dizziness, syncope, lightheadedness[Ref]


Common (1% to 10%): Decrease in blood pressure and/or orthostatic hypotension with reflex tachycardia and symptoms/signs of cerebral ischemia (including drowsiness and dizziness and weakness) with first time use and when the dose is increased

Uncommon (0.1% to 1%): Marked decreases in blood pressure with an aggravation of symptomatic angina pectoris, collapse associated with bradycardia and cardiac rhythm disturbances

Frequency not reported: Pallor, crescendo angina, rebound hypertension, hypotension[Ref]


Common (1% to 10%): Peripheral edema in patients treated for left ventricular failure[Ref]


Uncommon (0.1% to 1%): Allergic skin reactions

Very rare (less than 0.01%): Exfoliative dermatitis/Stevens-Johnson Syndrome or angioedema

Frequency not reported: Cutaneous vasodilation with flushing, excessive perspiration, rash[Ref]


Uncommon (0.1% to 1%): Nausea and vomiting

Frequency not reported: Heartburn[Ref]


Very rare (less than 0.01%): Pituitary apoplexy in patients with undiagnosed pituitary tumors[Ref]


Very rare (less than 0.01%): Angle closure glaucoma[Ref]


Very rare (less than 0.01%): Alveolar hypoventilation with consequent hypoxemia and the risk of developing a myocardial infarction in patients with coronary heart disease[Ref]


Frequency not reported: Methemoglobinemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase-deficient syndrome[Ref]


Frequency not reported: Restlessness[Ref]


1. Product Information. Isordil (isosorbide dinitrate). Wyeth-Ayerst Laboratories. 2002;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.