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Hyqvia Side Effects

Generic name: hyaluronidase / immune globulin

Medically reviewed by Last updated on May 30, 2022.

Note: This document contains side effect information about hyaluronidase / immune globulin. Some dosage forms listed on this page may not apply to the brand name Hyqvia.


More frequent side effects include: fever, nausea, and vomiting. Continue reading for a comprehensive list of adverse effects.

Applies to hyaluronidase/immune globulin: subcutaneous solution.


Subcutaneous route (Kit)

Thrombosis may occur with immune globulin/recombinant human hyaluronidase in patients with or without known risk factors. Risk factors may include advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling central vascular catheters, hyperviscosity, and cardiovascular risk factors. Adequate hydration prior to administration is recommended. Administer at the minimum dose and infusion rate practicable in patients at risk of thrombosis. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.

Serious side effects of Hyqvia

Along with its needed effects, hyaluronidase / immune globulin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hyaluronidase / immune globulin:

More common

  • Fever

Other side effects of Hyqvia

Some side effects of hyaluronidase / immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • nausea
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • unusual tiredness or weakness
  • vomiting

Less common

  • Itching, redness, swelling, discomfort, or pain at the infusion site

For Healthcare Professionals

Applies to hyaluronidase / immune globulin: subcutaneous solution.


The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]


Very common (10% or more): Local reaction (51.9%)

Frequency not reported: Local pain and swelling, discomfort/pain, erythema, pruritus[Ref]

Nervous system

Very common (10% or more): Headache (21%), fatigue (11.1%)

Postmarketing reports: Transient ischemic attack, tremor, burning sensation, cerebrovascular accident, coma, seizures, loss of consciousness[Ref]


Very common (10% or more): Antibodies to recombinant human hyaluronidase (18%)[Ref]


Very common (10% or more): Systemic adverse reaction (67.9%)

Common (1% to 10%): Pyrexia

Frequency not reported: Fever, back injury, transient swelling from abdominal infusion site to genitalia

Postmarketing reports: Edema, rigors[Ref]


Common (1% to 10%): Nausea, vomiting

Postmarketing reports: Abdominal pain[Ref]


Frequency not reported: Acute intravascular hemolysis

Postmarketing reports: Leukopenia, pancytopenia[Ref]


Frequency not reported: Acute renal dysfunction/failure[Ref]


Postmarketing reports: Hypotension, hypertension, myocardial infarction, chest pain, cardiac arrest, vascular collapse[Ref]


Postmarketing reports: Pulmonary edema, dyspnea, oxygen saturation decreased, cyanosis, hypoxemia, bronchospasm, apnea, acute respiratory distress syndrome (ARDS)[Ref]


Postmarketing reports: Hyperhidrosis, allergic dermatitis, bullous dermatitis, epidermolysis, erythema multiforme, Stevens-Johnson Syndrome[Ref]


Postmarketing reports: Hepatic dysfunction[Ref]


Postmarketing reports: Anxiety, insomnia[Ref]


Postmarketing reports: Back pain[Ref]


1. "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation (2014):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.