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Hyqvia Side Effects

Generic Name: hyaluronidase / immune globulin

Note: This document contains side effect information about hyaluronidase / immune globulin. Some of the dosage forms listed on this page may not apply to the brand name Hyqvia.

In Summary

More frequent side effects include: fever, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hyaluronidase / immune globulin: subcutaneous solution

Along with its needed effects, hyaluronidase / immune globulin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hyaluronidase / immune globulin:

More common
  • Fever

Some side effects of hyaluronidase / immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
  • nausea
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • unusual tiredness or weakness
  • vomiting
Less common
  • Itching, redness, swelling, discomfort, or pain at the infusion site

For Healthcare Professionals

Applies to hyaluronidase / immune globulin: subcutaneous solution

General

The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]

Local

Very common (10% or more): Local reaction (51.9%)
Frequency not reported: Local pain and swelling, discomfort/pain, erythema, pruritus[Ref]

Nervous system

Very common (10% or more): Headache (21%), fatigue (11.1%)
Postmarketing reports: Transient ischemic attack, tremor, burning sensation, cerebrovascular accident, coma, seizures, loss of consciousness[Ref]

Immunologic

Very common (10% or more): Antibodies to recombinant human hyaluronidase (18%)[Ref]

Other

Very common (10% or more): Systemic adverse reaction (67.9%)
Common (1% to 10%): Pyrexia
Frequency not reported: Fever, back injury, transient swelling from abdominal infusion site to genitalia
Postmarketing reports: Edema, rigors[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting
Postmarketing reports: Abdominal pain[Ref]

Hematologic

Frequency not reported: Acute intravascular hemolysis
Postmarketing reports: Leukopenia, pancytopenia[Ref]

Renal

Frequency not reported: Acute renal dysfunction/failure[Ref]

Cardiovascular

Postmarketing reports: Hypotension, hypertension, myocardial infarction, chest pain, cardiac arrest, vascular collapse[Ref]

Respiratory

Postmarketing reports: Pulmonary edema, dyspnea, oxygen saturation decreased, cyanosis, hypoxemia, bronchospasm, apnea, acute respiratory distress syndrome (ARDS)[Ref]

Dermatologic

Postmarketing reports: Hyperhidrosis, allergic dermatitis, bullous dermatitis, epidermolysis, erythema multiforme, Stevens-Johnson Syndrome[Ref]

Hepatic

Postmarketing reports: Hepatic dysfunction[Ref]

Psychiatric

Postmarketing reports: Anxiety, insomnia[Ref]

Musculoskeletal

Postmarketing reports: Back pain[Ref]

References

1. "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation, Deerfield, IL.

Some side effects of Hyqvia may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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