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Hyqvia Side Effects

Generic Name: hyaluronidase / immune globulin

Note: This page contains information about the side effects of hyaluronidase / immune globulin. Some of the dosage forms included on this document may not apply to the brand name Hyqvia.

In Summary

More frequent side effects include: fever, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hyaluronidase / immune globulin: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by hyaluronidase / immune globulin. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking hyaluronidase / immune globulin, check with your doctor or nurse immediately:

More common:
  • Fever

Minor Side Effects

Some of the side effects that can occur with hyaluronidase / immune globulin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Headache
  • nausea
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Itching, redness, swelling, discomfort, or pain at the infusion site

For Healthcare Professionals

Applies to hyaluronidase / immune globulin: subcutaneous solution


The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]


Very common (10% or more): Local reaction (51.9%)
Frequency not reported: Local pain and swelling, discomfort/pain, erythema, pruritus[Ref]

Nervous system

Very common (10% or more): Headache (21%), fatigue (11.1%)
Postmarketing reports: Transient ischemic attack, tremor, burning sensation, cerebrovascular accident, coma, seizures, loss of consciousness[Ref]


Very common (10% or more): Antibodies to recombinant human hyaluronidase (18%)[Ref]


Very common (10% or more): Systemic adverse reaction (67.9%)
Common (1% to 10%): Pyrexia
Frequency not reported: Fever, back injury, transient swelling from abdominal infusion site to genitalia
Postmarketing reports: Edema, rigors[Ref]


Common (1% to 10%): Nausea, vomiting
Postmarketing reports: Abdominal pain[Ref]


Frequency not reported: Acute intravascular hemolysis
Postmarketing reports: Leukopenia, pancytopenia[Ref]


Frequency not reported: Acute renal dysfunction/failure[Ref]


Postmarketing reports: Hypotension, hypertension, myocardial infarction, chest pain, cardiac arrest, vascular collapse[Ref]


Postmarketing reports: Pulmonary edema, dyspnea, oxygen saturation decreased, cyanosis, hypoxemia, bronchospasm, apnea, acute respiratory distress syndrome (ARDS)[Ref]


Postmarketing reports: Hyperhidrosis, allergic dermatitis, bullous dermatitis, epidermolysis, erythema multiforme, Stevens-Johnson Syndrome[Ref]


Postmarketing reports: Hepatic dysfunction[Ref]


Postmarketing reports: Anxiety, insomnia[Ref]


Postmarketing reports: Back pain[Ref]


1. "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation, Deerfield, IL.

Not all side effects for Hyqvia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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