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Hyqvia Side Effects

Generic Name: hyaluronidase / immune globulin

Note: This page contains information about the side effects of hyaluronidase / immune globulin. Some of the dosage forms included on this document may not apply to the brand name Hyqvia.

In Summary

More frequent side effects include: fever, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hyaluronidase / immune globulin: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by hyaluronidase / immune globulin. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking hyaluronidase / immune globulin, check with your doctor or nurse immediately:

More common:
  • Fever

Minor Side Effects

Some of the side effects that can occur with hyaluronidase / immune globulin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Headache
  • nausea
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Itching, redness, swelling, discomfort, or pain at the infusion site

For Healthcare Professionals

Applies to hyaluronidase / immune globulin: subcutaneous solution

General

The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]

Local

Very common (10% or more): Local reaction (51.9%)
Frequency not reported: Local pain and swelling, discomfort/pain, erythema, pruritus[Ref]

Nervous system

Very common (10% or more): Headache (21%), fatigue (11.1%)
Postmarketing reports: Transient ischemic attack, tremor, burning sensation, cerebrovascular accident, coma, seizures, loss of consciousness[Ref]

Immunologic

Very common (10% or more): Antibodies to recombinant human hyaluronidase (18%)[Ref]

Other

Very common (10% or more): Systemic adverse reaction (67.9%)
Common (1% to 10%): Pyrexia
Frequency not reported: Fever, back injury, transient swelling from abdominal infusion site to genitalia
Postmarketing reports: Edema, rigors[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting
Postmarketing reports: Abdominal pain[Ref]

Hematologic

Frequency not reported: Acute intravascular hemolysis
Postmarketing reports: Leukopenia, pancytopenia[Ref]

Renal

Frequency not reported: Acute renal dysfunction/failure[Ref]

Cardiovascular

Postmarketing reports: Hypotension, hypertension, myocardial infarction, chest pain, cardiac arrest, vascular collapse[Ref]

Respiratory

Postmarketing reports: Pulmonary edema, dyspnea, oxygen saturation decreased, cyanosis, hypoxemia, bronchospasm, apnea, acute respiratory distress syndrome (ARDS)[Ref]

Dermatologic

Postmarketing reports: Hyperhidrosis, allergic dermatitis, bullous dermatitis, epidermolysis, erythema multiforme, Stevens-Johnson Syndrome[Ref]

Hepatic

Postmarketing reports: Hepatic dysfunction[Ref]

Psychiatric

Postmarketing reports: Anxiety, insomnia[Ref]

Musculoskeletal

Postmarketing reports: Back pain[Ref]

References

1. "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation, Deerfield, IL.

Not all side effects for Hyqvia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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