Skip to main content

Hyqvia Side Effects

Generic name: hyaluronidase / immune globulin

Medically reviewed by Drugs.com. Last updated on Apr 23, 2025.

Note: This document provides detailed information about Hyqvia Side Effects associated with hyaluronidase / immune globulin. Some dosage forms listed on this page may not apply specifically to the brand name Hyqvia.

Applies to hyaluronidase / immune globulin: subcutaneous solution.

Important warnings This medicine can cause some serious health issues

Subcutaneous route (kit)

Warning: Thrombosis. Thrombosis may occur with immune globulin products, including immune globulin/recombinant human hyaluronidase.

Risk factors may include advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling vascular catheters, hyperviscosity and cardiovascular risk factors.

Thrombosis may occur in the absence of known risk factors.For patients at risk of thrombosis, administer immune globulin/recombinant human hyaluronidase at the minimum dose and infusion rate practicable.

Ensure adequate hydration in patients before administration.Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.

Precautions

It is very important that your doctor check your progress at regular visits for any problems that may be caused by this medicine. Blood and urine tests may be needed to check for unwanted effects.

While you are being treated with this medicine, do not have any immunizations (vaccines) without your doctor's approval. Do not use mumps, rubella, and varicella vaccine for up to 6 months or measles vaccine for 1 year while using this medicine.

This medicine may cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hives, chest pain, dizziness or lightheadedness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. Certain people, including those with IgA (an immunoglobulin) deficiency and antibodies against IgA and a history of hypersensitivity to human immunoglobulin or hyaluronidase products should not use this medicine.

This medicine may cause blood clots. This is more likely to occur if you have a history of blood clotting problems, heart disease, or atherosclerosis (hardening of the arteries), or if you are obese, take medicines containing estrogen, or must stay in bed for a long time because of surgery or illness. Check with your doctor right away if you suddenly have chest pain, shortness of breath, a severe headache, leg pain, or problems with vision, speech, or walking.

Check with your doctor right away if you start to have a stiff neck, drowsiness, fever, severe headache, nausea, vomiting, painful eye movements, or eye sensitivity to light. These could be symptoms of a serious condition called aseptic meningitis syndrome (AMS).

This medicine may cause bleeding (hemolysis). Tell your doctor right away if you have stomach or back pain, dark urine, decreased urination, difficulty with breathing, an increased heart rate, tiredness, or yellow eyes or skin after you receive the medicine.

Check with your doctor right away if you start having red or dark brown urine, lower back or side pain, a sudden weight gain, a swollen face, arms, or legs, decreased urine output, or any problems with urination after you receive this medicine. These may be symptoms of a serious kidney problem.

Check with your doctor right away if you start having chest pain, difficult, fast, or noisy breathing, sometimes with wheezing, blue lips and fingernails, fever, pale skin, increased sweating, coughing that sometimes produces a pink frothy sputum, shortness of breath, or swelling of the legs and ankles after receiving this medicine. These may be symptoms of a serious lung problem.

This medicine is made from donated human blood. Some human blood products have transmitted certain viruses (eg, Creutzfeldt-Jakob disease) to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Hyqvia

Along with its needed effects, hyaluronidase / immune globulin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hyaluronidase / immune globulin:

More common side effects

  • fever

Other side effects of Hyqvia

Some side effects of hyaluronidase / immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • headache
  • nausea
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • unusual tiredness or weakness
  • vomiting

Less common side effects

  • itching, redness, swelling, discomfort, or pain at the injection site

For healthcare professionals

Applies to hyaluronidase / immune globulin: subcutaneous solution.

General adverse events

The most common adverse events were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.[Ref]

Local

Nervous system

Immunologic

Other

Gastrointestinal

Hematologic

Renal

Cardiovascular

Respiratory

Dermatologic

Hepatic

Psychiatric

Musculoskeletal

See also:

References

1. (2014) "Product Information. Hyqvia (hyaluronidase-immune globulin)." Baxter Healthcare Corporation

Further information

Hyqvia side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.