Hyaluronan Side Effects

• Consumer
• Professional

In Summary

Commonly reported side effects of hyaluronan include: arthralgia and headache. Other side effects include: back pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hyaluronan: intra-articular gel, intra-articular solution

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• bleeding;

• increased knee pain; or

• signs of infection (warmth, swelling, redness) around your knee.

Common side effects may include:

• joint pain, stiffness, or swelling;

• itching, numbness, or tingling;

• headache, dizziness;

• back pain;

• swelling, pain, redness, or mild discomfort where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hyaluronan: intra-articular gel, intra-articular solution

Local

Uncommon (0.1% to 1%): Injection site erythema, injection site edema^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (13%)

Common (1% to 10%): Arthritis, back pain

Uncommon (0.1% to 1%): Arthropathy, joint disorder, joint effusion, joint stiffness, joint swelling, aggravated osteoarthritis, localized osteoarthritis, knee arthroplasty^[Ref]

Other

Uncommon (0.1% to 1%): Baker's cyst, bursitis^[Ref]

Nervous system

Very common (10% or more): Headache (12%)^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Erythema, edema^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer