Hyaluronan Side Effects

Applies to hyaluronan: intra-articular gel, intra-articular solution.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• bleeding;

• increased knee pain; or

• signs of infection (warmth, swelling, redness) around your knee.

Common side effects may include:

• joint pain, stiffness, or swelling;

• itching, numbness, or tingling;

• headache, dizziness;

• back pain;

• swelling, pain, redness, or mild discomfort where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:

For healthcare professionals

Applies to hyaluronan: intra-articular gel, intra-articular solution.

Local adverse events

• Uncommon (0.1% to 1%): Injection site erythema, injection site edema^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (13%)
• Common (1% to 10%): Arthritis, back pain
• Uncommon (0.1% to 1%): Arthropathy, joint disorder, joint effusion, joint stiffness, joint swelling, aggravated osteoarthritis, localized osteoarthritis, knee arthroplasty^[Ref]

Other

• Uncommon (0.1% to 1%): Baker's cyst, bursitis^[Ref]

Nervous system

• Very common (10% or more): Headache (12%)^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Erythema, edema^[Ref]

Frequently asked questions

• How long does Juvéderm last?

Further information

Hyaluronan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer