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Hexalen Side Effects

Generic Name: altretamine

Note: This document contains side effect information about altretamine. Some of the dosage forms listed on this page may not apply to the brand name Hexalen.

In Summary

Common side effects of Hexalen include: peripheral neuropathy, anemia, and nausea and vomiting. Other side effects include: leukopenia, and thrombocytopenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to altretamine: oral capsules

    Experience of Supervising Clinician
  • Use only under the supervision of a clinician experienced in therapy with antineoplastic agents.1

    Dose-Related Toxicities
  • Monitor peripheral blood counts at least monthly, prior to initiation of each course of therapy, and as clinically indicated.1

  • Risk of neurotoxicity.1 Perform neurologic examinations regularly during therapy.1

Side effects include:

Nausea, vomiting, peripheral sensory neuropathy, leukopenia, thrombocytopenia, anemia, increased serum alkaline phosphatase, increased serum creatinine/BUN.

For Healthcare Professionals

Applies to altretamine: oral capsule

Hematologic

Very common (10% or more): Anemia (33%)

Common (1% to 10%): Thrombocytopenia, leukopenia[Ref]

Gastrointestinal

Very common (10% or more): Nausea and vomiting (33%)

Common (1% to 10%): Increased alkaline phosphatase[Ref]

Nervous system

Very common (10% or more): Peripheral sensory neuropathy (31%)

Common (1% to 10%): Seizures

Frequency not reported: CNS symptoms (mood disorders, disorders of consciousness, ataxia, dizziness, vertigo)[Ref]

Renal

Common (1% to 10%): Increased BUN, increased serum creatinine[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia[Ref]

Other

Uncommon (0.1% to 1%): Fatigue[Ref]

Hepatic

Frequency not reported: Hepatic toxicity[Ref]

Dermatologic

Frequency not reported: Skin rash, pruritus, alopecia[Ref]

References

1. "Product Information. Hexalen Capsules (altretamine)." US Bioscience, West Conshohoken, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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