Medically reviewed by Drugs.com. Last updated on Nov 2, 2021.
Generic name: ALTRETAMINE 50mg
Dosage form: capsule
HEXALEN® capsules is administered orally. Doses are calculated on the basis of body surface area.
HEXALEN® capsules may be administered either for 14 or 21 consecutive days in a 28 day cycle at a dose of 260 mg/m2/day. The total daily dose should be given as 4 divided oral doses after meals and at bedtime. There is no pharmacokinetic information supporting this dosing regimen and the effect of food on HEXALEN® capsules bioavailability or pharmacokinetics has not been evaluated.
HEXALEN® capsules should be temporarily discontinued (for 14 days or longer) and subsequently restarted at 200 mg/m2/day for any of the following situations:
- Gastrointestinal intolerance unresponsive to symptomatic measures;
- White blood count <2000/mm3 or granulocyte count <1000/mm3;
- Platelet count <75,000/mm3;
- Progressive neurotoxicity.
If neurologic symptoms fail to stabilize on the reduced dose schedule, HEXALEN® capsules should be discontinued indefinitely.
Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published (2-9). There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.
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- Drug class: miscellaneous antineoplastics
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