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Glycopyrrolate Side Effects

For the Consumer

Applies to glycopyrrolate: oral solution, oral tablet

Along with its needed effects, glycopyrrolate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glycopyrrolate:

More common
  • Body aches or pain
  • chills
  • constipation
  • cough
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • difficulty with breathing
  • ear congestion
  • feeling of warmth
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • painful urination
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Abdominal or stomach discomfort or pain
  • abdominal or stomach distension
  • chest pain
  • confusion
  • convulsions
  • dizziness
  • dry heaves
  • dry mouth
  • fainting
  • increase in heart rate
  • lightheadedness
  • pain or tenderness around the eyes and cheekbones
  • rapid breathing
  • shortness of breath or troubled breathing
  • stuffy nose
  • sunken eyes
  • thirst
  • tightness in the chest
  • vomiting
  • wheezing
  • wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking glycopyrrolate:

  • low blood pressure
  • muscle weakness
  • trouble breathing

Some side effects of glycopyrrolate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Altered mood
  • anxiety
  • attack, assault, or force
  • bloated
  • change in taste
  • chapped lips
  • crying
  • dry skin
  • dry tongue
  • excess air or gas in the stomach or intestines
  • full feeling
  • hyperventilation
  • irregular heartbeats
  • irritability
  • loss of taste
  • moaning
  • nervousness
  • pain
  • paleness of the skin
  • passing gas
  • rash
  • restlessness
  • shaking
  • trouble with sleeping
  • uncontrolled eye movements

For Healthcare Professionals

Applies to glycopyrrolate: compounding powder, inhalation capsule, injectable solution, oral solution, oral tablet

Nervous system

Nervous system side effects have included headache, nervousness, drowsiness, dizziness, insomnia, and mental confusion. The elderly appear to be more prone to the anticholinergic effects of glycopyrrolate on the CNS. Seizures have been reported from postmarketing experience.[Ref]


Cardiovascular side effects have included tachycardia and palpitations. In addition, cardiac arrhythmias, cardiac arrest, hypertension, and hypotension have been reported from postmarketing experience.[Ref]


Gastrointestinal side effects have included dry mouth, nausea, vomiting, constipation, and feeling bloated.[Ref]


Genitourinary side effects have included urinary hesitancy, urinary retention, and impotence.[Ref]


Ocular side effects have included blurred vision, increased ocular tension, cycloplegia, and dilatation of the pupil.[Ref]


Endocrine side effects have included suppression of lactation.[Ref]


Dermatologic side effects have included dry mucous membranes and decreased sweating.[Ref]


General side effects have included weakness, hyperpyrexia, and a loss of taste.[Ref]


Hypersensitivity side effects have included urticaria and other dermal manifestations.[Ref]


Immunologic side effects have included anaphylaxis.[Ref]


Local side effects have included pruritus, edema, erythema, and pain at the injection site.[Ref]


Respiratory side effects have included nasal congestion, nasal dryness, and sinusitis.[Ref]


1. "Product Information. Glycopyrrolate (glycopyrrolate)." American Regent Laboratories Inc, Shirley, NY.

2. Grum DF, Osborne LR "Central anticholinergic syndrome following glycopyrrolate." Anesthesiology 74 (1991): 191-3

3. Shamsai J "Central anticholinergic syndrome: does it exist?" Anesthesiology 74 (1991): 1158

4. Wingard DW "Glycopyrrolate and the central anticholinergic syndrome." Anesthesiology 75 (1991): 1125-6

5. Madan V, Beck MH "Urinary retention caused by topical glycopyrrolate for hyperhidrosis." Br J Dermatol 155 (2006): 634-5

6. "Product Information. Cuvposa (glycopyrrolate)." Shionogi USA Inc, Florham Park, NJ.

Some side effects of glycopyrrolate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.