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Glycopyrrolate Dosage

Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.

Applies to the following strengths: 1 mg; 2 mg; 0.2 mg/mL; 15.6 mcg; 1 mg/5 mL; 1.5 mg; 100%; 0.2 mg/mL preservative-free; 25 mcg/mL; 1.7 mg

Usual Adult Dose for Anesthesia

Preanesthetic: 0.004 mg/kg intramuscularly 30 to 60 minutes prior to anticipated induction of anesthesia.

Intraoperative: 0.1 mg intravenously; repeat every 2 to 3 minutes as needed


Neuromuscular blockage reversal: 0.2 mg for each 1.0 mg neostigmine or 5.0 mg pyridostigmine

Comments:

Uses: During anesthesia induction and intubation, to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions, and to block cardiac vagal inhibitory reflexes

Usual Adult Dose for Peptic Ulcer

Oral tablets:
1 mg oral tablets: 1 mg orally 3 times a day (morning, afternoon, and bedtime)

2 mg oral tablets: 2 mg orally twice to 3 times a day at equally spaced intervals
Maximum dose: 8 mg daily


Injection solution:
0.1 mg intramuscularly or intravenously every 4 hours three or four times a day
Maximum dose: 4 doses per day


Comments:

Uses: Adjunctive treatment of peptic ulcer

Usual Adult Dose for Chronic Obstructive Pulmonary Disease - Maintenance

Solution for inhalation: Inhale contents of one vial twice a day using accompanying nebulization system

Capsules for inhalation: Inhale contents of one capsule twice a day using accompanying inhaler

Comments:


Use: Long term maintenance treatment of airflow obstruction in chronic obstructive pulmonary disease (COPD) including chronic bronchitis and/or emphysema

Usual Pediatric Dose for Anesthesia

Preanesthetic: 0.004 mg/kg intramuscularly 30 to 60 minutes prior to anticipated induction of anesthesia.


Intraoperative: 0.004 mg intravenously; repeat every 2 to 3 minutes as needed
Maximum dose: 0.1 mg per single dose

Neuromuscular blockage reversal: 0.2 mg for each 1.0 mg neostigmine or 5.0 mg pyridostigmine

Comments:

Uses: During anesthesia induction and intubation, to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions, and to block cardiac vagal inhibitory reflexes

Usual Pediatric Dose for Excessive Salivation

1 mg/5 mL oral liquid, children 3 to 16 years:
Initial dose: 0.02 mg/kg orally 3 times a day, at least one hour before or 2 hours after meals

Maximum dose: 0.1 mg/kg 3 times a day, not to exceed 1.5 to 3 mg per dose based on weight

Use: To reduce chronic severe drooling in patients aged 3 to 16 years with conditions associated with problem drooling (e.g. cerebral palsy)

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution is recommended. (intravenous solution)
No adjustment recommended for mild to moderate renal impairment (inhalation powder/solution)
Use with caution (oral tablets)

Liver Dose Adjustments

No adjustment recommended (inhalation powder)
Use with caution (oral tablets)

Precautions


Safety and efficacy of the inhalation powder have not been established in patients younger than 18 years.

Safety and efficacy of the oral tablets have not been established in patients younger than 12 years.

Safety and efficacy of the oral liquid have not been established in patients younger than 3 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

IV compatibility:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.