Skip to Content

Glycopyrrolate Dosage

Applies to the following strength(s): 1 mg ; 2 mg ; 0.2 mg/mL ; 15.6 mcg ; 1 mg/5 mL ; 1.5 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anesthesia

Preanesthetic (reduction of secretions): 0.004 mg (0.02 mL)/kg IM 30 to 60 minutes prior to the anticipated time of induction of anesthesia or at the time the preanesthetic narcotic and/or sedative are administered.

Intraoperative: 0.1 mg (0.5 mL) IV repeated as needed every 2 to 3 minutes.

Reversal of neuromuscular blockade: 0.2 mg (1.0 mL) IV for each 1.0 mg of neostigmine or 5 mg of pyridostigmine.

Reversal of bradycardia, vagal reflexes (intraoperative): 0.1 mg IV repeated as needed at 2 to 3 minute intervals.

Usual Adult Dose for Peptic Ulcer

Parenteral: 0.1 mg (0.5 mL) IV or IM every 4 hours, 3 to 4 times daily. If a more profound effect is required the dose may be increased to 0.2 mg (1 mL).

1 mg oral tablet:
Initial dose: 1 mg orally 3 times daily or 1 mg in the morning, 1 mg in the early afternoon, and 2 mg at bedtime.
Maintenance dose: 1 mg orally twice daily to a maximum of 8 mg per day.

2 mg oral tablet: 2 mg orally 2 to 3 times daily to a maximum of 8 mg per day.

1.5 mg oral tablet: Used to provide intermediate titration doses based on patient response.

Usual Pediatric Dose for Anesthesia

Preanesthetic: 0.004 mg (0.02 mL)/kg IM 30 to 60 minutes prior to the anticipated time of induction of anesthesia or at the time the preanesthetic narcotic and/or sedative are administered. Children under 2 years of age may require up to 0.009 mg (0.45 mL)/kg.

Intraoperative: 0.004 mg (0.02 mL)/kg IV not to exceed 0.1 mg (0.5 mL) in a single dose, repeated as needed every 2 to 3 minutes.

Reversal of neuromuscular blockade: 0.4 mg (2 mL)/kg IV for each 1 mg of neostigmine or 5 mg of pyridostigmine.

Reversal of bradycardia, vagal reflexes (intraoperative): 4 mcg/kg/dose IV (maximum dose: 100 mcg/dose) at 2 to 3 minute intervals.

Usual Pediatric Dose for Excessive Salivation

3 years to 16 years with neurologic conditions associated with problem drooling:

Initiate dosing at 0.02 mg/kg orally three times daily and titrate in increments of 0.02 mg/kg every 5 to 7 days, based on therapeutic response and adverse reactions. Maximum recommended dose is 0.1 mg/kg three times daily, not to exceed 1.5 to 3 mg per dose based upon weight. Administer at least one hour before or two hours after meals.

Renal Dose Adjustments

Elimination is severely impaired in renal failure; dosage adjustment recommended.

Liver Dose Adjustments

Data not available

Precautions

Glycopyrrolate injectable contains benzyl alcohol and is not recommended for use in neonates.

Caution is recommended when glycopyrrolate is given to elderly patients because of the increased risk of side effects. The elderly appear to be more prone to the anticholinergic effects of glycopyrrolate on the CNS, which can result in confusion, agitation, delirium, or drowsiness.

Dialysis

Data not available

Hide