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Glipizide / metformin Side Effects

In Summary

More frequently reported side effects include: decreased vitamin b12 serum concentrate. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to glipizide / metformin: oral tablet

Along with its needed effects, glipizide/metformin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glipizide / metformin:

More Common

Less Common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • pounding in the ears
  • slow heartbeat

Rare

  • Abdominal discomfort
  • decreased appetite
  • diarrhea
  • fainting spells
  • fast, shallow breathing
  • general feeling of discomfort
  • muscle pain or cramping
  • shortness of breath
  • sleepiness

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking glipizide / metformin:

  • Abdominal discomfort
  • anxiety
  • behavior change, similar to drunkenness
  • blurred vision
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • decreased appetite
  • diarrhea
  • difficulty in concentrating
  • drowsiness
  • excessive hunger
  • fast heartbeat
  • fast, shallow breathing
  • general feeling of discomfort
  • headache
  • muscle pain or cramping
  • nausea
  • nervousness
  • nightmares
  • restless sleep
  • seizures
  • shakiness
  • slurred speech
  • unusual sleepiness
  • unusual tiredness or weakness

Some side effects of glipizide / metformin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Muscle or bone pain
  • stomach pain
  • vomiting

For Healthcare Professionals

Applies to glipizide / metformin: oral tablet

Metabolic

Metabolic side effects, including lactic acidosis, which is a potentially fatal metabolic complication of biguanide therapy, has been reported in patients receiving metformin. The incidence of lactic acidosis has been about 0.03 cases per 1,000 patient years with approximately 0.015 fatal cases per 1,000 patient-years. The risk of lactic acidosis is particularly high in patients with underlying renal insufficiency. Cases of lactic acidosis occurring in patients with normal renal function have been rarely reported. Concomitant cardiovascular or liver disease, sepsis, and hypoxia may also increase the risk of lactic acidosis.[Ref]

Glipizide-Metformin:

Very Common (10% or more): Hypoglycemia (up to 12.6%)

Glipizide:

Common (1% to 10%): Hypoglycemia

Metformin:

Rare (less than 0.1%): Lactic acidosis[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 18.4%)

Common (1% to 10%): Nausea/vomiting, abdominal pain[Ref]

Hematologic

Glipizide:

Frequency not reported: Hemolytic anemia

Postmarketing reports: Hemolytic anemia in patients not known to have G6PD deficiency

Metformin:

Common (1% to 10%): Subnormal vitamin B12 levels

Frequency not reported: Anemia[Ref]

Hepatic

Glipizide:

Rare (less than 0.1%): Cholestatic and hepatocellular hepatic injury accompanied by jaundice[Ref]

Respiratory

Very common (10% or more): Upper respiratory infection (up to 10.3%)[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Cardiovascular

Common (1% to 10%): Hypertension[Ref]

Nervous system

Very common (10% or more): Headache (up to 12.6%)

Common (1% to 10%): Dizziness[Ref]

Musculoskeletal

Common (1% to 10%):: Musculoskeletal pain.[Ref]

References

1. "Product Information. Metaglip (glipizide-metformin)." Bristol-Myers Squibb, Princeton, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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