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Fusilev Side Effects

Generic name: levoleucovorin

Medically reviewed by Last updated on Jun 27, 2022.

Note: This document contains side effect information about levoleucovorin. Some dosage forms listed on this page may not apply to the brand name Fusilev.


More frequent side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.

Applies to levoleucovorin: intravenous powder for solution, intravenous solution.

Serious side effects of Fusilev

Along with its needed effects, levoleucovorin (the active ingredient contained in Fusilev) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking levoleucovorin:

More common

  • Belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • chest tightness
  • cracked, dry, scaly skin
  • fever
  • heartburn
  • indigestion
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • stomach discomfort, upset, or pain
  • stomach distention
  • swelling of the mouth
  • troubled breathing
  • watery or bloody diarrhea

Incidence not known

  • Cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • feeling unusually cold
  • hives, itching, skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shivering
  • unusual tiredness or weakness

Other side effects of Fusilev

Some side effects of levoleucovorin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bad unusual or unpleasant (after)taste
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • change in taste
  • confusion
  • decreased appetite
  • nausea
  • sensation of pins and needles
  • stabbing pain
  • thinning or loss of hair
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to levoleucovorin: intravenous powder for injection, intravenous solution.


Very common (10% or more): Stomatitis (37.5%), vomiting (37.5%), nausea (18.8%)

Common (1% to 10%): Diarrhea, dyspepsia, typhlitis[Ref]


Common (1% to 10%): Dyspnea[Ref]


Common (1% to 10%): Dermatitis

Postmarketing reports: Pruritus, rash[Ref]


Postmarketing reports: Temperature change, rigors[Ref]

Nervous system

Common (1% to 10%): Neuropathy, taste perversion[Ref]


Common (1% to 10%): Renal function abnormal[Ref]


Postmarketing reports: Possible allergic reactions


Frequency not reported: Leukopenia, thrombocytopenia


Common (1% to 10%): Confusion


1. "Product Information. Levoleucovorin (levoleucovorin)." Spectrum Chemical (2008):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.