Fusilev Side Effects
Generic name: levoleucovorin
Medically reviewed by Drugs.com. Last updated on Jun 27, 2022.
Note: This document contains side effect information about levoleucovorin. Some dosage forms listed on this page may not apply to the brand name Fusilev.
More frequent side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.
Applies to levoleucovorin: intravenous powder for solution, intravenous solution.
Serious side effects of Fusilev
Along with its needed effects, levoleucovorin (the active ingredient contained in Fusilev) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking levoleucovorin:
- blistering, crusting, irritation, itching, or reddening of the skin
- chest tightness
- cracked, dry, scaly skin
- sores, ulcers, or white spots on the lips, tongue, or inside the mouth
- stomach discomfort, upset, or pain
- stomach distention
- swelling of the mouth
- troubled breathing
- watery or bloody diarrhea
Incidence not known
- difficulty swallowing
- fast heartbeat
- feeling unusually cold
- hives, itching, skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- unusual tiredness or weakness
Other side effects of Fusilev
Some side effects of levoleucovorin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bad unusual or unpleasant (after)taste
- burning, tingling, numbness or pain in the hands, arms, feet, or legs
- change in taste
- decreased appetite
- sensation of pins and needles
- stabbing pain
- thinning or loss of hair
- weight loss
For Healthcare Professionals
Applies to levoleucovorin: intravenous powder for injection, intravenous solution.
Very common (10% or more): Stomatitis (37.5%), vomiting (37.5%), nausea (18.8%)
Common (1% to 10%): Dermatitis
Postmarketing reports: Temperature change, rigors[Ref]
Common (1% to 10%): Neuropathy, taste perversion[Ref]
Common (1% to 10%): Renal function abnormal[Ref]
Postmarketing reports: Possible allergic reactions
Frequency not reported: Leukopenia, thrombocytopenia
Common (1% to 10%): Confusion
More about Fusilev (levoleucovorin)
- Check interactions
- Latest FDA alerts (1)
- Dosage information
- During pregnancy
- Generic availability
- FDA approval history
- Drug class: antidotes
Related treatment guides
1. "Product Information. Levoleucovorin (levoleucovorin)." Spectrum Chemical (2008):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.