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Frovatriptan Side Effects

In Summary

More frequently reported side effects include: dizziness, fatigue, paresthesia, and flushing. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to frovatriptan: oral tablet

Along with its needed effects, frovatriptan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking frovatriptan:

Less common
  • Changes in vision
  • chest pain
  • fast, irregular, pounding, or racing heartbeat or pulse
  • increased sweating
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • bloody diarrhea
  • cold fingers or toes
  • confusion
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fainting
  • fever
  • headache, sudden, severe, and continuing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • numbness or tingling of the fingers or toes
  • overactive reflexes
  • pain spreading to the left shoulder
  • paleness or cold feeling in the fingertips and toes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • shivering
  • skin rash, hives, or itching skin
  • talking or acting with excitement you cannot control
  • tightness in the chest, throat, neck, and jaw
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • weakness in the legs

Some side effects of frovatriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Acid or sour stomach
  • belching
  • bone pain
  • continuing ringing or buzzing or other unexplained noise in the ears
  • dry mouth
  • feeling of warmth
  • hearing loss
  • heartburn
  • hot or cold sensation
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • redness of the face, neck, arms, and occasionally upper chest
  • stomach discomfort or upset
  • stuffy or runny nose
  • trouble sleeping
Incidence not known

For Healthcare Professionals

Applies to frovatriptan: oral tablet


The most commonly reported adverse events included dizziness, fatigue, paraesthesia, headache, and vascular flushing.[Ref]


Postmarketing reports: Hypersensitivity reactions including cutaneous disorders, angioedema, and anaphylactic reactions[Ref]


Common (1% to 10%): Flushing, chest discomfort
Uncommon (0.1% to 1%): Palpitations, tachycardia, peripheral coldness, hypertension, chest pain
Rare (0.01% to 0.1%): Bradycardia
Postmarketing reports: Myocardial infarction, coronary arteriospasm[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, dysesthesia, hypoesthesia , somnolence
Uncommon (0.1% to 1%): Dysgeusia, tremor, disturbance in attention. lethargy, sedation, vertigo, involuntary muscle contractions
Rare (0.01% to 0.1%): Amnesia hypertonia hypotonia, hyporeflexia, movement disorder
Postmarketing reports: Seizure[Ref]


Uncommon (0.1% to 1%): Anxiety, insomnia, confusional state, nervousness, agitation, depression, depersonalization
Rare (0.01% to 0.1%): Abnormal dreams, personality disorder[Ref]


Common (1% to 10%): Dry mouth, dyspepsia, vomiting, nausea, abdominal pain, diarrhea
Uncommon (0.1% to 1%): Dysphagia, flatulence, constipation, anorexia, esophagospasm, increased salivation
Rare (0.01% to 0.1%): Change in bowel habits, chelitis, eructation, gastroesophageal reflux, hiccough, peptic ulcer, salivary gland pain, stomatitis, toothache, lip blister, lip pain , oral mucosal blistering, peptic ulcer, salivary gland pain[Ref]


Common (1% to 10%): Skeletal pain
Uncommon (0.1% to 1%): Musculoskeletal stiffness, musculoskeletal pain, pain in extremity, back pain, arthralgia[Ref]


Common (1% to 10%): Throat tightness
Uncommon (0.1% to 1%): Rhinitis, sinusitis, pharyngolaryngeal pain
Rare (0.01% to 0.1%): Epistasis, hiccups, hyperventilation, respiratory disorder, throat irritation[Ref]


Common (1% to 10%): Visual disturbance
Uncommon (0.1% to 1%): Eye pain, eye irritation, photophobia
Rare (0.01% to 0.1%): Night blindness[Ref]


Common (1% to 10%): Hyperhidrosis
Uncommon (0.1% to 1%): Pruritus
Rare (0.01% to 0.1%): Erythema, piloerection, urticaria, purpura[Ref]


Common (1% to 10%): Fatigue, hot or cold sensation, tinnitus
Uncommon (0.1% to 1%): Ear pain, ear discomfort, ear disorder, ear pruritus, hyperacusis, feeling hot temperature intolerance, asthenia, sluggishness, energy increased, malaise
Rare (0.01% to 0.1%): Pyrexia[Ref]


Uncommon (0.1% to 1%): Increased micturition frequency, polyuria
Rare (0.01% to 0.1%): Nocturia, renal pain, abnormal urine analysis[Ref]


Uncommon (0.1% to 1%): Dehydration, thirst
Rare (0.01% to 0.1%): Hypoglycemia[Ref]


Rare (0.01% to 0.1%): Lymphadenopathy[Ref]


Rare (0.01% to 0.1%): Increased blood bilirubin[Ref]


Uncommon (0.1% to 1%): Breast tenderness[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Frova (frovatriptan)." Endo Laboratories LLC, Chadds Ford, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.