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Frovatriptan Side Effects

In Summary

More frequently reported side effects include: dizziness, fatigue, paresthesia, and flushing. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to frovatriptan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by frovatriptan. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking frovatriptan:

Less common:
  • Changes in vision
  • chest pain
  • fast, irregular, pounding, or racing heartbeat or pulse
  • increased sweating
Incidence not known:
  • Abdominal or stomach pain
  • agitation
  • bloody diarrhea
  • cold fingers or toes
  • confusion
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fainting
  • fever
  • headache, sudden, severe, and continuing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • numbness or tingling of the fingers or toes
  • overactive reflexes
  • pain spreading to the left shoulder
  • paleness or cold feeling in the fingertips and toes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • shivering
  • skin rash, hives, or itching skin
  • talking or acting with excitement you cannot control
  • tightness in the chest, throat, neck, and jaw
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • weakness in the legs

Minor Side Effects

Some of the side effects that can occur with frovatriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Acid or sour stomach
  • belching
  • bone pain
  • continuing ringing or buzzing or other unexplained noise in the ears
  • dry mouth
  • feeling of warmth
  • hearing loss
  • heartburn
  • hot or cold sensation
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • redness of the face, neck, arms, and occasionally upper chest
  • stomach discomfort or upset
  • stuffy or runny nose
  • trouble sleeping
Incidence not known:
  • Seizures

For Healthcare Professionals

Applies to frovatriptan: oral tablet


The most commonly reported adverse events included dizziness, fatigue, paraesthesia, headache, and vascular flushing.[Ref]


Postmarketing reports: Hypersensitivity reactions including cutaneous disorders, angioedema, and anaphylactic reactions[Ref]


Common (1% to 10%): Flushing, chest discomfort
Uncommon (0.1% to 1%): Palpitations, tachycardia, peripheral coldness, hypertension, chest pain
Rare (0.01% to 0.1%): Bradycardia
Postmarketing reports: Myocardial infarction, coronary arteriospasm[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, dysesthesia, hypoesthesia , somnolence
Uncommon (0.1% to 1%): Dysgeusia, tremor, disturbance in attention. lethargy, sedation, vertigo, involuntary muscle contractions
Rare (0.01% to 0.1%): Amnesia hypertonia hypotonia, hyporeflexia, movement disorder
Postmarketing reports: Seizure[Ref]


Uncommon (0.1% to 1%): Anxiety, insomnia, confusional state, nervousness, agitation, depression, depersonalization
Rare (0.01% to 0.1%): Abnormal dreams, personality disorder[Ref]


Common (1% to 10%): Dry mouth, dyspepsia, vomiting, nausea, abdominal pain, diarrhea
Uncommon (0.1% to 1%): Dysphagia, flatulence, constipation, anorexia, esophagospasm, increased salivation
Rare (0.01% to 0.1%): Change in bowel habits, chelitis, eructation, gastroesophageal reflux, hiccough, peptic ulcer, salivary gland pain, stomatitis, toothache, lip blister, lip pain , oral mucosal blistering, peptic ulcer, salivary gland pain[Ref]


Common (1% to 10%): Skeletal pain
Uncommon (0.1% to 1%): Musculoskeletal stiffness, musculoskeletal pain, pain in extremity, back pain, arthralgia[Ref]


Common (1% to 10%): Throat tightness
Uncommon (0.1% to 1%): Rhinitis, sinusitis, pharyngolaryngeal pain
Rare (0.01% to 0.1%): Epistasis, hiccups, hyperventilation, respiratory disorder, throat irritation[Ref]


Common (1% to 10%): Visual disturbance
Uncommon (0.1% to 1%): Eye pain, eye irritation, photophobia
Rare (0.01% to 0.1%): Night blindness[Ref]


Common (1% to 10%): Hyperhidrosis
Uncommon (0.1% to 1%): Pruritus
Rare (0.01% to 0.1%): Erythema, piloerection, urticaria, purpura[Ref]


Common (1% to 10%): Fatigue, hot or cold sensation, tinnitus
Uncommon (0.1% to 1%): Ear pain, ear discomfort, ear disorder, ear pruritus, hyperacusis, feeling hot temperature intolerance, asthenia, sluggishness, energy increased, malaise
Rare (0.01% to 0.1%): Pyrexia[Ref]


Uncommon (0.1% to 1%): Increased micturition frequency, polyuria
Rare (0.01% to 0.1%): Nocturia, renal pain, abnormal urine analysis[Ref]


Uncommon (0.1% to 1%): Dehydration, thirst
Rare (0.01% to 0.1%): Hypoglycemia[Ref]


Rare (0.01% to 0.1%): Lymphadenopathy[Ref]


Rare (0.01% to 0.1%): Increased blood bilirubin[Ref]


Uncommon (0.1% to 1%): Breast tenderness[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Frova (frovatriptan)." Endo Laboratories LLC, Chadds Ford, PA.

Not all side effects for frovatriptan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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