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Fleet EZ-Prep Side Effects

Generic Name: sodium biphosphate / sodium phosphate

Note: This document contains side effect information about sodium biphosphate / sodium phosphate. Some of the dosage forms listed on this page may not apply to the brand name Fleet EZ-Prep.

For the Consumer

Applies to sodium biphosphate / sodium phosphate: oral liquid, oral solution, oral tablet

Other dosage forms:

Along with its needed effects, sodium biphosphate/sodium phosphate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium biphosphate / sodium phosphate:

More common Incidence not known
  • Agitation
  • bloody or cloudy urine
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • coma
  • confusion
  • cough
  • decreased urine output
  • depression
  • difficult or labored breathing
  • difficult or painful urination
  • difficulty with swallowing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • hostility
  • irritability
  • lethargy
  • muscle twitching
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • redness of the skin
  • seizures
  • skin rash, hives or welts, or itching
  • stupor
  • swelling of the face, ankles, or hands
  • tightness in the chest
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking sodium biphosphate / sodium phosphate:

Symptoms of overdose
  • Abdominal or stomach cramps
  • blurred vision
  • chest pain or discomfort
  • decreased frequency of urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • increase in heart rate
  • increased thirst
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain
  • pounding or rapid pulse
  • rapid breathing
  • restlessness
  • sunken eyes
  • sweating
  • tremor
  • weakness
  • weight gain
  • wrinkled skin

For Healthcare Professionals

Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet, rectal enema


The most common adverse events were abdominal bloating, nausea, abdominal pain, and vomiting.[Ref]


Very common (10% or more): Bloating (39%), nausea (37%), abdominal pain (24%), vomiting (10%)[Ref]


Postmarketing reports: Renal impairment, increased blood urea nitrogen (BUN), increased creatinine, acute renal failure, acute phosphate nephropathy, nephrocalcinosis, renal tubular necrosis[Ref]

Nervous system

Postmarketing reports: Seizures[Ref]


Postmarketing reports: Arrhythmias[Ref]


Postmarketing reports: Hypersensitivity reactions (including anaphylaxis, rash, pruritus, urticaria, throat tightness, bronchospasm, dyspnea, pharyngeal edema, dysphagia, paresthesia, swelling of the lips and tongue, and facial swelling)[Ref]


1. "Product Information. OsmoPrep (sodium biphosphate-sodium phosphate)." Valeant Pharmaceuticals, Costa Mesa, CA.

Some side effects of Fleet EZ-Prep may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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