Estradiol / Norethindrone Topical Side Effects
Applies to estradiol/norethindrone topical: topical film extended release.
General adverse events
General side effects including headache (18% to 20%), asthenia (8% to 12%), back pain (9% to 11%), flu syndrome (5% to 9%), pain (4% to 6%), and accidental injury (4% to 5%) have been reported. Postmarketing side effects include increased weight.[Ref]
Respiratory
Respiratory side effects including rhinitis (7% to 13%), respiratory disorder (7% to 12%), pharyngitis (4% to 10%), and sinusitis (4% to 9%) were reported.[Ref]
Gastrointestinal
Gastrointestinal side effects including nausea (8% to 11%), abdominal pain (6% to 7%), diarrhea (4% to 5%), flatulence (4% to 5%), and dyspepsia (1% to 5%) were reported.[Ref]
Local
Local side effects including reaction at the application site (2% to 6%) has been reported.[Ref]
Genitourinary
Genitourinary side effects including breast pain (25% to 31%), dysmenorrhea (20% to 21%), vaginitis (6% to 13%), menstrual disorder (6% to 12%), suspicious Papanicolaou smear (4% to 8%), and leukorrhea (5%). Postmarketing side effects include endometrial hyperplasia, endocervical polyp, uterine leiomyomata, fallopian tube cyst, uterine spasms, and breast cancer.[Ref]
Psychiatric
Psychiatric side effects including nervousness (3% to 6%) and depression (3% to 6%) have been reported.[Ref]
Hypersensitivity
Hypersensitivity side effects include postmarketing reports of angioedema and hypersensitivity.
Cardiovascular
Cardiovascular side effects include postmarketing reports of hypertension and varicose veins.
Dermatologic
Dermatologic side effects include postmarketing reports of skin discoloration.
Hepatic
Hepatic side effects include postmarketing reports of jaundice cholestatic, cholelithiasis, gall bladder disorder, and increased transaminases.
Nervous system
Nervous system side effects include postmarketing reports of affect lability, libido disorder, migraine, vertigo, and paraesthesia.
See also:
Activella
Activella is used for atrophic urethritis, atrophic vaginitis, hypoestrogenism, postmenopausal symptoms
Angeliq
Angeliq (drospirenone and estradiol) is used to treat the symptoms of menopause such as hot ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Bijuva
Bijuva (estradiol and progesterone) is used to reduce moderate to severe hot flashes in menopausal ...
Climara Pro
Climara Pro (estradiol and levonorgestrel) treats menopause symptoms and helps prevent ...
CombiPatch
CombiPatch is used for atrophic urethritis, atrophic vaginitis, hypoestrogenism, postmenopausal symptoms
Covaryx
Covaryx is used for hot flashes, menopausal disorders, postmenopausal symptoms
Covaryx HS
Covaryx HS is used for hot flashes, menopausal disorders, postmenopausal symptoms
Duavee
Duavee (bazedoxifene/conjugated estrogens) is used to treat hot flashes and prevent postmenopausal ...
References
1. (2022) "Product Information. Combipatch (estradiol-norethindrone)." Apothecon Inc
More about estradiol / norethindrone topical
Further information
Estradiol/norethindrone topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.