Estradiol / norethindrone topical Side Effects
Applies to estradiol/norethindrone topical: topical film extended release
Genitourinary side effects including breast pain (25% to 31%), dysmenorrhea (20% to 21%), vaginitis (6% to 13%), menstrual disorder (6% to 12%), suspicious Papanicolaou smear (4% to 8%), and leukorrhea (5%). Postmarketing side effects include endometrial hyperplasia, endocervical polyp, uterine leiomyomata, fallopian tube cyst, uterine spasms, and breast cancer.[Ref]
Local side effects including reaction at the application site (2% to 6%) has been reported.[Ref]
General side effects including headache (18% to 20%), asthenia (8% to 12%), back pain (9% to 11%), flu syndrome (5% to 9%), pain (4% to 6%), and accidental injury (4% to 5%) have been reported. Postmarketing side effects include increased weight.[Ref]
Hypersensitivity side effects include postmarketing reports of angioedema and hypersensitivity.
Cardiovascular side effects include postmarketing reports of hypertension and varicose veins.
Dermatologic side effects include postmarketing reports of skin discoloration.
1. "Product Information. CombiPatch (estradiol-norethindrone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
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Some side effects may not be reported. You may report them to the FDA.