Skip to main content

Emcin Clear Side Effects

Generic name: erythromycin topical

Medically reviewed by Last updated on Feb 22, 2021.

Note: This document contains side effect information about erythromycin topical. Some of the dosage forms listed on this page may not apply to the brand name Emcin Clear.

For the Consumer

Applies to erythromycin topical: topical gel/jelly, topical pad, topical powder, topical solution

Side effects requiring immediate medical attention

Along with its needed effects, erythromycin topical (the active ingredient contained in Emcin Clear) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects not requiring immediate medical attention

Some side effects of erythromycin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For erythromycin ointment

Less common

  • Peeling
  • redness

For erythromycin pledget (swab), topical gel, or topical liquid form

More common

  • Dry or scaly skin
  • irritation
  • itching
  • stinging or burning feeling

Less common

  • Peeling
  • redness

For Healthcare Professionals

Applies to erythromycin topical: topical gel, topical ointment, topical solution, topical swab


The most commonly reported side effects included burning, dryness, erythema, itching, and peeling.[Ref]


Very common (10% or more): Burning/burning sensation (up to 25%)

Uncommon (0.1% to 1%): Desquamation, dryness, erythema, itching, oiliness, peeling[Ref]


Frequency not reported: Mild to severe skin irritation, skin tenderness[Ref]


Frequency not reported: Generalized urticarial reaction[Ref]

Generalized urticarial reactions required systemic steroid treatment.[Ref]


Frequency not reported: Eye irritation[Ref]


1. "Product Information. A/T/S 2% Topical Gel (erythromycin topical)" Hoechst Marion-Roussel Inc, Kansas City, MO.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Akne-Mycin (erythromycin topical)" Healthpoint, Fort Worth, TX.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.