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Dramamine Original Formula Side Effects

Generic name: dimenhydrinate

Medically reviewed by Last updated on Jun 12, 2023.

Note: This document contains side effect information about dimenhydrinate. Some dosage forms listed on this page may not apply to the brand name Dramamine Original Formula.

Applies to dimenhydrinate: oral solution, oral tablets, parenteral injection.

Side effects include:

Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.

Paradoxical CNS stimulation in pediatric patients and occasionally in adults.

With IM injection: Pain at the injection site.

Because dimenhydrinate (the active ingredient contained in Dramamine Original Formula) contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.

For Healthcare Professionals

Applies to dimenhydrinate: compounding powder, injectable solution, oral liquid, oral tablet, oral tablet chewable.


The most frequently reported adverse reaction is drowsiness.[Ref]


Frequency not reported: Tachycardia[Ref]


Frequency not reported: Skin rash[Ref]


Frequency not reported: Dry mouth, epigastric distress, nausea[Ref]


Frequency not reported: Difficult or painful urination[Ref]


Frequency not reported: Anorexia[Ref]

Nervous system

Frequency not reported: Drowsiness, dizziness, headache, excitation[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Lassitude[Ref]


Frequency not reported: Nervousness, restlessness, insomnia[Ref]


Frequency not reported: Dry nose, dry throat, thickening of bronchial secretions[Ref]

More about Dramamine Original Formula (dimenhydrinate)

Patient resources

Other brands

Dramamine, Triptone, Dramamine for Kids, Driminate, Travel-Eze

Professional resources

Related treatment guides


1. Product Information. Dramamine (dimenhydrinate). Pharmacia and Upjohn. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.