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Dornase alfa Side Effects

In Summary

Commonly reported side effects of dornase alfa include: transient skin rash and voice disorder. Other side effects include: laryngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dornase alfa: inhalation solution

In addition to its needed effects, some unwanted effects may be caused by dornase alfa. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dornase alfa:

More common:
  • Body aches or pain
  • chest pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • trouble breathing
  • trouble swallowing
  • voice changes

Minor Side Effects

Some of the side effects that can occur with dornase alfa may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • rash
  • sneezing
  • stomach discomfort, upset, or pain
  • stuffy nose
Less common:
  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

For Healthcare Professionals

Applies to dornase alfa: inhalation solution

Dermatologic

Very common (10% or more): Rash (up to 12%)
Rare (less than 0.1%): Urticaria[Ref]

Musculoskeletal

Very common (10% or more): Chest pain (up to 25%)[Ref]

Other

Very common (10% or more): Fever (up to 32%), voice alteration (up to 18%)[Ref]

Respiratory

Very common (10% or more): Pharyngitis (up to 40%), rhinitis (up to 30%), dyspnea (up to 17%)
Common (1% to 10%): Laryngitis, Force Vita Capacity (FVC) decreased of 10% of predicted
Rare (less than 0.1%): Chest pain (pleuritic/non-cardiac), dysphonia, pulmonary function tests decreased[Ref]

Gastrointestinal

Common (1% to 10%): Dyspepsia[Ref]

Immunologic

Common (1% to 10%): Development of serum antibodies (2% to 4%)[Ref]

Ocular

Common (1% to 10%): Conjunctivitis[Ref]

References

1. "Product Information. Pulmozyme (dornase alfa)." Genentech, South San Francisco, CA.

2. Bryson HM, Sorkin EM "Dornase alfa. A review of its pharmacological properties and therapeutic potential in cystic fibrosis." Drugs 48 (1994): 894-906

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. Witt DM, Anderson L "Dornase alfa: a new option in the management of cystic fibrosis." Pharmacotherapy 16 (1996): 40-8

5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for dornase alfa may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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