Dornase Alfa Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the clinical use of dornase alpha (hamster) during breastfeeding. Because it is given by inhalation and is a large protein molecule with a molecular weight of about 37,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. A task force respiratory experts from Europe, Australia and New Zealand found that dornase alfa is compatible with breastfeeding.[1]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
1.
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 2020;55:1901208. [PubMed: 31699837]
Substance Identification
Substance Name
Dornase Alfa
CAS Registry Number
143831-71-4
Drug Class
Breast Feeding
Lactation
Milk, Human
Enzymes
Deoxyribonuclease I
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
