Dornase Alfa Dosage
Medically reviewed by Drugs.com. Last updated on Jul 4, 2025.
Applies to the following strengths: 2.5 mg/2.5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cystic Fibrosis
2.5 mg (1 single-use ampule) inhaled orally once daily using a recommended nebulizer/compressor system
Comment:
- Some patients may benefit from twice daily administration.
Use:
- Coadministration with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function
- To reduce the risk of respiratory tract infections requiring parenteral antibiotics in CF patients with a Force Vital Capacity (FVC) of 40% or more
Usual Pediatric Dose for Cystic Fibrosis
5 years or older:
2.5 mg (1 single-use ampule) inhaled orally once daily using a recommended nebulizer/compressor system
Comment:
- Some patients may benefit from twice daily administration.
Uses:
- Coadministration with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function
- To reduce the risk of respiratory tract infections requiring parenteral antibiotics in CF patients with a Force Vital Capacity (FVC) of 40% or more
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Safety and efficacy have not been established in patients younger than 5 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- For oral inhalation only.
- Administer via nebulizer system or via a jet nebulizer connected to an air compressor with an adequate air flow and equipped with a mouthpiece or suitable face mask.
- Do not dilute or mix with other drugs in the nebulizer.
- The manufacturer's instructions on the use and maintenance of the equipment, including cleaning and disinfection procedures should be followed.
Storage requirements:
- Store ampules in their protective foil pouch under refrigeration and protected from light.
- Refrigerate ampules during transport and do not expose to room temperatures for a total time of 24 hours.
- Each ampule should be squeezed prior to use in order to check for leaks.
- Discard if the solution is cloudy or discolored. Once opened, the entire contents of the ampule should be used or discarded.
More about dornase alfa
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- Drug class: miscellaneous respiratory agents
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Further information
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