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Dornase Alfa Dosage

Medically reviewed on December 15, 2017.

Applies to the following strengths: 2.5 mg/2.5 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cystic Fibrosis

2.5 mg (1 single-use ampule) inhaled orally once daily using a recommended nebulizer/compressor system

Comment:
-Some patients may benefit from twice daily administration.

Use:
-Coadministration with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function
-To reduce the risk of respiratory tract infections requiring parenteral antibiotics in CF patients with a Force Vital Capacity (FVC) of 40% or more

Usual Pediatric Dose for Cystic Fibrosis

5 years or older:
2.5 mg (1 single-use ampule) inhaled orally once daily using a recommended nebulizer/compressor system

Comment:
-Some patients may benefit from twice daily administration.

Uses:
-Coadministration with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function
-To reduce the risk of respiratory tract infections requiring parenteral antibiotics in CF patients with a Force Vital Capacity (FVC) of 40% or more

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 5 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-For oral inhalation only.
-Administer via nebulizer system or via a jet nebulizer connected to an air compressor with an adequate air flow and equipped with a mouthpiece or suitable face mask.
-Do not dilute or mix with other drugs in the nebulizer.
-The manufacturer's instructions on the use and maintenance of the equipment, including cleaning and disinfection procedures should be followed.

Storage requirements:
-Store ampules in their protective foil pouch under refrigeration and protected from light.
-Refrigerate ampules during transport and do not expose to room temperatures for a total time of 24 hours.
-Each ampule should be squeezed prior to use in order to check for leaks.
-Discard if the solution is cloudy or discolored. Once opened, the entire contents of the ampule should be used or discarded.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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