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Dopamine Side Effects

For the Consumer

Applies to dopamine: parenteral injection concentrate for iv infusion, parenteral injection for iv infusion

Side effects include:

Dopamine may cause cardiac conduction abnormalities (e.g., ventricular arrhythmia, atrial fibrillation, widened QRS complex, ectopic heartbeats), tachycardia, angina, palpitation, bradycardia, vasoconstriction, hypotension, hypertension, dyspnea, nausea, vomiting, headache, anxiety, azotemia, piloerection, and gangrene of the extremities.

For Healthcare Professionals

Applies to dopamine: intravenous solution

Cardiovascular

Gangrene of the feet occurred in patients with preexisting vascular disorders and/or at doses of at least 10 to 14 mcg/kg/min given for prolonged periods of time.

Ventricular arrhythmias occurred at very high doses.[Ref]

Common (1% to 10%): Ectopic beats, tachycardia, anginal pain, palpitation, hypotension, vasoconstriction

Uncommon (0.1% to 1%): Aberrant ventricular conduction/ventricular arrhythmia, bradycardia, widened QRS complex, hypertension

Frequency not reported: Gangrene of the feet/extremities, peripheral cyanosis, fatal ventricular arrhythmias, atrial fibrillation, cardiac conduction abnormalities[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Respiratory

Common (1% to 10%): Dyspnea[Ref]

Dermatologic

Very rare (less than 0.01%): Gangrene

Frequency not reported: Piloerection[Ref]

Local

Necrosis and tissue sloughing may be caused by extravasation of this drug.[Ref]

Frequency not reported: Necrosis, tissue sloughing, local ischemia and vasoconstriction[Ref]

Psychiatric

Frequency not reported: Anxiety[Ref]

Renal

Frequency not reported: Azotemia[Ref]

Ocular

Frequency not reported: Mydriasis[Ref]

Metabolic

Frequency not reported: Hypovolemia[Ref]

References

1. "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals, Wilmington, DE.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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