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Diroximel fumarate Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 14, 2021.

For the Consumer

Applies to diroximel fumarate: oral capsule delayed release

Side effects requiring immediate medical attention

Along with its needed effects, diroximel fumarate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking diroximel fumarate:

Less common

  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination

Incidence not known

  • Back pain
  • bloating of the stomach
  • blurred vision
  • confusion
  • dark urine
  • difficulty with swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • headache
  • hives, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • stomach pain
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of diroximel fumarate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • feeling of warmth
  • redness of the face, neck, arms and occasionally, upper chest

Less common

For Healthcare Professionals

Applies to diroximel fumarate: oral delayed release capsule

Hematologic

Common (1% to 10%): Lymphopenia[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis, angioedema[Ref]

Immunologic

Frequency not reported: Progressive multifocal leukoencephalopathy (PML), serious infections[Ref]

Genitourinary

Common (1% to 10%): Albumin urine present[Ref]

Hepatic

Common (1% to 10%): Aspartate aminotransferase increased

Frequency not reported: Liver injury

Postmarketing reports: Liver function abnormalities (elevations in transaminases 3 times ULN or greater with concomitant elevations in total bilirubin greater than 2 times ULN)[Ref]

Cardiovascular

Very common (10% or more): Flushing (40%)[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash, erythema[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain (18%), diarrhea (14%), nausea (12%)

Common (1% to 10%): Vomiting[Ref]

Frequently asked questions

References

1. "Product Information. Vumerity (diroximel fumarate)." Alkermes, Inc, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.