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Diroximel Fumarate Dosage

Medically reviewed by Drugs.com. Last updated on Jan 9, 2020.

Applies to the following strengths: 231 mg

Usual Adult Dose for Multiple Sclerosis

Initial dose: 231 mg orally 2 times a day for 7 days, then increase to 462 mg orally 2 times a day
Maintenance dose: 462 mg orally 2 times a day; temporary dose reductions to 231 mg 2 times a day may be considered for individuals who do not tolerate the maintenance dose; within 4 weeks the recommended dose of 462 mg 2 times a day should be resumed; consider discontinuing therapy in patients unable to tolerate return to the maintenance dose

Comments:
-Administration of nonenteric coated aspirin (up to 325 mg) 30 minutes prior to this drug may reduce the incidence/severity of flushing.

Use: For the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease

Renal Dose Adjustments

Mild renal impairment: No adjustment recommended.
Moderate or severe renal impairment: Not recommended.

Liver Dose Adjustments

No adjustment recommended.

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-Hypersensitivity to dimethyl fumarate
-Concomitant use of dimethyl fumarate

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Swallow capsules whole and intact; do not crush, chew, or sprinkle on food.
-If this drug is taken with food, avoid a high-fat, high-calorie meal/snack; the meal/snack should contain no more than 700 calories and no more than 30 g fat.
-Do not consume alcohol when taking this drug.

Storage requirements:
-Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).

Monitoring:
-Obtain a complete blood cell count (CBC), including lymphocyte count, 6 months after initiation of therapy and every 6 to 12 months thereafter, as clinically indicated.
-Obtain serum aminotransferase, alkaline phosphatase, and total bilirubin levels during this drug.

Patient advice:
-Do not drink alcohol while taking this drug.
-Stop taking this drug and notify your healthcare provider immediately if you experience welts, hives, swelling of the face, lips, mouth or tongue, difficulty breathing, weakness on one side of the body, vision problems, clumsiness of your arms or legs, changes in thinking or memory, or personality changes.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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