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DepoDur Side Effects

Generic name: morphine liposomal

Note: This document provides detailed information about DepoDur.

Applies to morphine liposomal: injectable suspension extended release Side Effects associated with morphine liposomal. Some dosage forms listed on this page may not apply specifically to the brand name DepoDur.

Applies to morphine liposomal: injectable suspension extended release.

General

The more commonly reported side effects have included nausea, pruritus, pyrexia, vomiting, hypotension, anemia, headache, constipation, decreased oxygen saturation, urinary retention, and dizziness.[Ref]

Respiratory

Prolonged and serious respiratory depression was reported when administration was associated with subarachnoid puncture. In these cases, respiratory depression occurred following apparent recovery from anesthesia (within 12 hours of administration).

Four percent of patients receiving this drug in clinical trials required treatment with narcotic antagonists for respiratory depression; 90% of respiratory depression events were reported within the first 24 hours. Delayed respiratory depression (occurring up to 48 hours postdose) was reported in 2% of patients; 0.6% of patients reported respiratory depression after more than 48 hours. During the postmarketing period, severe respiratory depression involving apnea or respiratory arrest have been reported following administration of labeled doses.[Ref]

Nervous system

CNS depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported. In most cases, there was concomitant administration of different narcotics or hypnotic/sedative medications in the post-operative period.[Ref]

Cardiovascular

Gastrointestinal

Dermatologic

Musculoskeletal

Metabolic

Psychiatric

Hematologic

Genitourinary

References

1. (2004) "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC

Further information

DepoDur side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.