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DepoDur Side Effects

Generic Name: morphine liposomal

Note: This document contains side effect information about morphine liposomal. Some of the dosage forms listed on this page may not apply to the brand name DepoDur.

For the Consumer

Applies to morphine liposomal: epidural suspension

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Very bad dizziness or passing out.
  • Chest pain or pressure or a fast heartbeat.
  • Slow heartbeat.
  • Trouble breathing, slow breathing, or shallow breathing.
  • A burning, numbness, or tingling feeling that is not normal.
  • Seizures.
  • Trouble passing urine.
  • Very bad belly pain.
  • Very hard stools (constipation).
  • Feeling very tired or weak.
  • Fever or chills.
  • Very bad headache.
  • Sweating a lot.
  • A very bad and sometimes deadly health problem called serotonin syndrome may happen if you take this drug with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.
  • Taking an opioid drug like this drug may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Upset stomach or throwing up.
  • Hard stools (constipation).
  • Headache.
  • Not able to sleep.
  • Gas.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to morphine liposomal: injectable suspension extended release

Respiratory

Respiratory side effects including decreased oxygen saturation (>10%), hypoxia (5% to 10%), respiratory depression (2% to 5%), hypercapnia (2% to 5%), and dyspnea (2% to 5%) have been reported. During postmarketing experience, severe respiratory depression, involving apnea or respiratory arrest, and cardiac arrest have been reported following administration of labeled doses of morphine sulfate extended-release liposome injection.[Ref]

Four percent of the patients who received morphine liposomal in clinical trials required treatment with narcotic antagonists for respiratory depression. Ninety percent of events of respiratory depression were reported to have started within the first 24 hours after dosing with morphine liposomal. Respiratory depression occurred in 0.6% of patients after more than 48 hours.[Ref]

Cardiovascular

Cardiovascular side effects including hypotension (>10%), tachycardia (5% to 10%), hypertension (2% to 5%) and bradycardia (2% to 5%) have been reported.[Ref]

Genitourinary

Genitourinary side effects including urinary retention (>10%), bladder spasm (2% to 5%), and oliguria (2% to 5%) have been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects including vomiting (>10%), constipation (>10%), nausea (>10%), flatulence (5% to 10%), paralytic ileus (2% to 5%), dyspepsia (2% to 5%), and abdominal distention (2% to 5%) have been reported.[Ref]

Dermatologic

Dermatologic side effects including pruritus (>10%), hypoesthesia (2% to 5%), and increased sweating (2% to 5%) have been reported.[Ref]

General

General side effects including pyrexia (>10%), headache (>10%), dizziness (>10%), insomnia (5% to 10%), somnolence (2% to 5%), anxiety (2% to 5%), and back pain (2% to 5%) have been reported.[Ref]

Hematologic

Hematologic side effects including anemia (>10%), hypokalemia (2% to 5%), and decreased hematocrit (2% to 5%) have been reported.[Ref]

Musculoskeletal

Musculoskeletal side effects including rigors (2% to 5%) have been reported.[Ref]

Nervous system

Nervous system side effects including paresthesia (2% to 5%) have been reported. During postmarketing experience, central nervous system depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported following epidural administration of morphine sulfate extended-release liposome injection.[Ref]

In most of these cases with central nervous system depression following epidural administration of morphine sulfate extended-release liposome injection, there was concomitant administration of different narcotics or hypnotic/sedative medications in the postoperative period.[Ref]

Oncologic

Oncologic side effects have included an increase in DNA fragmentation when incubated in vitro with a human lymphoma cell line. In vivo, morphine has been reported to produce an increase in the frequency of micronuclei in bone marrow cells and immature red blood cells in the mouse micronucleus test and to induce chromosomal aberrations in murine lymphocytes and spermatids.[Ref]

Some of the in vivo clastogenic effects reported with morphine in mice may be directly related to increases in glucocorticoid levels produced by morphine in that species.[Ref]

References

1. "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC, Chadds Ford, PA.

Some side effects of DepoDur may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about DepoDur (morphine liposomal)

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Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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