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DepoDur Side Effects

Generic Name: morphine liposomal

Note: This document contains side effect information about morphine liposomal. Some of the dosage forms listed on this page may not apply to the brand name DepoDur.

For the Consumer

Applies to morphine liposomal: epidural suspension

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Very bad dizziness or passing out.
  • Chest pain or pressure or a fast heartbeat.
  • Slow heartbeat.
  • Trouble breathing, slow breathing, or shallow breathing.
  • A burning, numbness, or tingling feeling that is not normal.
  • Seizures.
  • Trouble passing urine.
  • Very bad belly pain.
  • Very hard stools (constipation).
  • Feeling very tired or weak.
  • Fever or chills.
  • Very bad headache.
  • Sweating a lot.
  • A very bad and sometimes deadly health problem called serotonin syndrome may happen if you take this drug with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.
  • Taking an opioid drug like this drug may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Upset stomach or throwing up.
  • Hard stools (constipation).
  • Headache.
  • Not able to sleep.
  • Gas.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

For Healthcare Professionals

Applies to morphine liposomal: injectable suspension extended release


The more commonly reported side effects have included nausea, pruritus, pyrexia, vomiting, hypotension, anemia, headache, constipation, decreased oxygen saturation, urinary retention, and dizziness.[Ref]


Very common (10% or more): Decreased oxygen saturation

Common (1% to 10%): Hypoxia, respiratory depression, hypercapnia, dyspnea

Postmarketing reports: Severe respiratory depression, involving apnea or respiratory arrest, and cardiac arrest[Ref]

Prolonged and serious respiratory depression was reported when administration was associated with subarachnoid puncture. In these cases, respiratory depression occurred following apparent recovery from anesthesia (within 12 hours of administration).

Four percent of patients receiving this drug in clinical trials required treatment with narcotic antagonists for respiratory depression; 90% of respiratory depression events were reported within the first 24 hours. Delayed respiratory depression (occurring up to 48 hours postdose) was reported in 2% of patients; 0.6% of patients reported respiratory depression after more than 48 hours. During the postmarketing period, severe respiratory depression involving apnea or respiratory arrest have been reported following administration of labeled doses.[Ref]

Nervous system

Postmarketing reports: Central nervous system depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy[Ref]

CNS depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported. In most cases, there was concomitant administration of different narcotics or hypnotic/sedative medications in the post-operative period.[Ref]


Very common (10% or more): Hypotension

Common (1% to 10%): Tachycardia, hypertension, bradycardia[Ref]


Very common (10% or more): Vomiting, constipation, nausea

Common (1% to 10%): Flatulence, paralytic ileus, dyspepsia, abdominal distension[Ref]


Very common (10% or more): Pruritus

Common (1% to 10%): Hypoesthesia, increased sweating[Ref]


Common (1% to 10%): Rigors[Ref]


Common (1% to 10%): Hypokalemia


Common (1% to 10%): Anxiety


Very common (10% or more): Anemia

Common (1% to 10%): Decreased hematocrit[Ref]


Very common (10% or more): Urinary retention

Common (1% to 10%): Bladder spasm, oliguria[Ref]


1. "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC, Chadds Ford, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about DepoDur (morphine liposomal)

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