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DepoDur Side Effects

Generic name: morphine liposomal

Note: This document contains side effect information about morphine liposomal. Some dosage forms listed on this page may not apply to the brand name DepoDur.

Applies to morphine liposomal: injectable suspension extended release.


The more commonly reported side effects have included nausea, pruritus, pyrexia, vomiting, hypotension, anemia, headache, constipation, decreased oxygen saturation, urinary retention, and dizziness.[Ref]


Very common (10% or more): Decreased oxygen saturation

Common (1% to 10%): Hypoxia, respiratory depression, hypercapnia, dyspnea

Postmarketing reports: Severe respiratory depression, involving apnea or respiratory arrest, and cardiac arrest[Ref]

Prolonged and serious respiratory depression was reported when administration was associated with subarachnoid puncture. In these cases, respiratory depression occurred following apparent recovery from anesthesia (within 12 hours of administration).

Four percent of patients receiving this drug in clinical trials required treatment with narcotic antagonists for respiratory depression; 90% of respiratory depression events were reported within the first 24 hours. Delayed respiratory depression (occurring up to 48 hours postdose) was reported in 2% of patients; 0.6% of patients reported respiratory depression after more than 48 hours. During the postmarketing period, severe respiratory depression involving apnea or respiratory arrest have been reported following administration of labeled doses.[Ref]

Nervous system

Postmarketing reports: Central nervous system depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy[Ref]

CNS depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported. In most cases, there was concomitant administration of different narcotics or hypnotic/sedative medications in the post-operative period.[Ref]


Very common (10% or more): Hypotension

Common (1% to 10%): Tachycardia, hypertension, bradycardia[Ref]


Very common (10% or more): Vomiting, constipation, nausea

Common (1% to 10%): Flatulence, paralytic ileus, dyspepsia, abdominal distension[Ref]


Very common (10% or more): Pruritus

Common (1% to 10%): Hypoesthesia, increased sweating[Ref]


Common (1% to 10%): Rigors[Ref]


Common (1% to 10%): Hypokalemia


Common (1% to 10%): Anxiety


Very common (10% or more): Anemia

Common (1% to 10%): Decreased hematocrit[Ref]


Very common (10% or more): Urinary retention

Common (1% to 10%): Bladder spasm, oliguria[Ref]


1. (2004) "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.