Crizotinib Side Effects
Commonly reported side effects of crizotinib include: increased serum alanine aminotransferase. Continue reading for a comprehensive list of adverse effects.
Applies to crizotinib: oral capsules.
Side effects include:
ALK-positive metastatic NSCLC (≥25%): Vision disorders, nausea, diarrhea, vomiting, edema, constipation, elevated aminotransferase concentrations, fatigue, decreased appetite, upper respiratory infection, dizziness, neuropathy.
For Healthcare Professionals
Applies to crizotinib: oral capsule.
Very common (10% or more): Vision disorders (e.g., diplopia, photophobia, photopsia, reduced visual acuity, blurred vision, vitreous floaters, visual impairment) (71%), ocular hypotension (19%)
Uncommon (0.1% to 1%): Severe vision loss[Ref]
Very common (10% or more): Bradycardia (19%)
Very common (10% or more): ALT elevation (79%), AST elevation (66%), increased alkaline phosphatase (19%)
Common (1% to 10%): Hepatic failure, increased gamma-glutamyl transferase[Ref]
Very common (10% or more): Neutropenia (22%), lymphopenia (18%), leukopenia (15%), anemia (15%)
Common (1% to 10%): Febrile neutropenia[Ref]
Very common (10% or more): Rash (13%)[Ref]
The most common adverse reactions (25% or more) are vision disorders, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, fatigue, decreased appetite, upper respiratory infection, dizziness, and neuropathy.[Ref]
Common (1% to 10%): Decreased blood testosterone (e.g., blood testosterone decreased, hypogonadism, secondary hypogonadism)
Uncommon (0.1% to 1%): Increased weight[Ref]
Very common (10% or more): Dysgeusia (26%), dizziness (e.g., balance disorder, dizziness, dizziness postural, presyncope) (26%), neuropathy (e.g., burning sensation, dysesthesia, formication, gait disturbance, hyperesthesia, hypoesthesia, hypotonia, motor dysfunction, muscle atrophy, muscular weakness, neuralgia, neuritis, neuropathy peripheral, neurotoxicity, paresthesia, peripheral motor neuropathy, peripheral sensorimotor neuropathy, peripheral sensory neuropathy, peroneal nerve palsy, polyneuropathy, sensory disturbance, skin burning sensation) (25%)[Ref]
swelling, localized edema, peripheral edema, periorbital edema (49%), fatigue (30%), pyrexia (19%)[Ref]
Common (1% to 10%): Renal cyst (e.g., renal abscess, renal cyst, renal cyst hemorrhage, renal cyst infection), acute renal injury[Ref]
Very common (10% or more): Pain in extremity (16%)
Common (1% to 10%): Muscle spasm, muscular weakness[Ref]
Frequently asked questions
- How to pronounce Xalkori?
- How long does it take for Xalkori to work?
- What cancers are treated with Xalkori?
More about crizotinib
- Check interactions
- Reviews (7)
- Dosage information
- During pregnancy
- Drug class: multikinase inhibitors
- En español
Related treatment guides
1. "Product Information. Xalkori (crizotinib)." Pfizer U.S. Pharmaceuticals Group (2011):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.