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Clotrimazole topical Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 14, 2022.

For the Consumer

Applies to clotrimazole topical: topical cream, topical solution

Side effects requiring immediate medical attention

Along with its needed effects, clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking clotrimazole topical:

  • Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine

For Healthcare Professionals

Applies to clotrimazole topical: compounding powder, topical cream, topical lotion, topical powder, topical solution, topical spray, vaginal cream with applicator, vaginal kit, vaginal tablet

Dermatologic

Dermatologic side effects have included erythema, stinging, blistering, peeling, edema, itching, burning, and general skin irritation. Contact dermatitis, confirmed by patch testing, has been documented.[Ref]

Genitourinary

Genitourinary system effects associated with intravaginal use have included burning, itching, cramping, pain, and bleeding. Vulvar lesions and rash have rarely been reported.[Ref]

References

1. Roller JA "Contact allergy to clotrimazole." Br Med J 2 (1978): 737

2. Ayala F, Balato N, Nappa P, Lembo G "Contact dermatitis from clotrimazole." Contact Dermatitis 12 (1985): 110

3. Grossman ME, Kalb RE "Contact dermatitis to clotrimazole." Cutis 36 (1985): 240-2

4. "Product Information. Mycelex (clotrimazole)." Bayer (2001):

5. Baes H "Contact dermatitis from clotrimazole." Contact Dermatitis 32 (1995): 187-8

6. Guess E, Lebherz T, Wolfson N "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." Am J Obstet Gynecol 152 (1985): 965-8

7. Samuels B, Wolfson N, Riley J, Singh JM "Clinical toxicology of clotrimazole when administered vaginally." Clin Toxicol 18 (1981): 41-5

8. Greenspan D, Debruin M, Pons V "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." J Acquir Immune Defic Syndr 6 (1993): 1311-6

9. Binder GL, Gardner HL, Brown D Jr, Wells J "Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis." Obstet Gynecol 56 (1980): 121-3

10. Ford LC, Lebherz TB, Kleinkopf V "A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis." Clin Ther 3 (1981): 344-8

11. Christensen S, Stein GE, Mummaw N "Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis." DICP 25 (1991): 582-5

12. Avery, Brogden RN, Speight TM, Pinder RM, Sawyer PR "Clotrimazole: a review of its antifungal activity and therapeutic efficacy." Drugs 9 (1975): 424-47

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.