Clotrimazole topical Side Effects
For the Consumer
Applies to clotrimazole topical: topical cream, topical lotion, topical solution
Along with its needed effects, clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking clotrimazole topical:
- Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine
For Healthcare Professionals
Applies to clotrimazole topical: compounding powder, topical cream, topical lotion, topical powder, topical solution, topical spray, vaginal cream with applicator, vaginal kit, vaginal tablet
Dermatologic
Dermatologic side effects have included erythema, stinging, blistering, peeling, edema, itching, burning, and general skin irritation. Contact dermatitis, confirmed by patch testing, has been documented.[Ref]
Genitourinary
Genitourinary system effects associated with intravaginal use have included burning, itching, cramping, pain, and bleeding. Vulvar lesions and rash have rarely been reported.[Ref]
References
1. "Product Information. Mycelex (clotrimazole)." Bayer, West Haven, CT.
2. Kalb RE, Grossman ME "Contact dermatitis to clotrimazole." Cutis 36 (1985): 240-2
3. Roller JA "Contact allergy to clotrimazole." Br Med J 2 (1978): 737
4. Baes H "Contact dermatitis from clotrimazole." Contact Dermatitis 32 (1995): 187-8
5. Balato N, Lembo G, Nappa P, Ayala F "Contact dermatitis from clotrimazole." Contact Dermatitis 12 (1985): 110
6. Lebherz TB, Ford LC, Kleinkopf V "A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis." Clin Ther 3 (1981): 344-8
7. Stein GE, Christensen S, Mummaw N "Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis." DICP 25 (1991): 582-5
8. Lebherz T, Guess E, Wolfson N "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." Am J Obstet Gynecol 152 (1985): 965-8
9. Pons V, Greenspan D, Debruin M "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." J Acquir Immune Defic Syndr 6 (1993): 1311-6
10. Wolfson N, Riley J, Samuels B, Singh JM "Clinical toxicology of clotrimazole when administered vaginally." Clin Toxicol 18 (1981): 41-5
11. Sawyer PR, Brogden RN, Pinder RM, Speight TM, Avery "Clotrimazole: a review of its antifungal activity and therapeutic efficacy." Drugs 9 (1975): 424-47
12. Brown D Jr, Binder GL, Gardner HL, Wells J "Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis." Obstet Gynecol 56 (1980): 121-3
Some side effects of clotrimazole topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: topical antifungals
Consumer resources
- Clotrimazole Cream, Ointment, and Solution
- Clotrimazole Vaginal Cream
- Clotrimazole topical
- Clotrimazole vaginal
- Clotrimazole Topical (Advanced Reading)
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