Clotrimazole Topical Side Effects
Medically reviewed by Drugs.com. Last updated on May 10, 2024.
Applies to clotrimazole topical: topical cream, topical lotion, topical solution.
Precautions
If your skin problem does not improve within 4 weeks, or if it becomes worse, check with your doctor.
Serious side effects
Along with its needed effects, clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking clotrimazole topical:
- Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine
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For healthcare professionals
Applies to clotrimazole topical: compounding powder, topical cream, topical lotion, topical ointment, topical powder, topical solution, topical spray, vaginal cream with applicator, vaginal kit, vaginal tablet.
Dermatologic adverse events
Dermatologic side effects have included erythema, stinging, blistering, peeling, edema, itching, burning, and general skin irritation. Contact dermatitis, confirmed by patch testing, has been documented.[Ref]
Genitourinary
Genitourinary system effects associated with intravaginal use have included burning, itching, cramping, pain, and bleeding. Vulvar lesions and rash have rarely been reported.[Ref]
References
1. Roller JA (1978) "Contact allergy to clotrimazole." Br Med J, 2, p. 737
2. Balato N, Lembo G, Nappa P, Ayala F (1985) "Contact dermatitis from clotrimazole." Contact Dermatitis, 12, p. 110
3. Kalb RE, Grossman ME (1985) "Contact dermatitis to clotrimazole." Cutis, 36, p. 240-2
4. (2001) "Product Information. Mycelex (clotrimazole)." Bayer
5. Baes H (1995) "Contact dermatitis from clotrimazole." Contact Dermatitis, 32, p. 187-8
6. Lebherz T, Guess E, Wolfson N (1985) "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." Am J Obstet Gynecol, 152, p. 965-8
7. Wolfson N, Riley J, Samuels B, Singh JM (1981) "Clinical toxicology of clotrimazole when administered vaginally." Clin Toxicol, 18, p. 41-5
8. Pons V, Greenspan D, Debruin M (1993) "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." J Acquir Immune Defic Syndr, 6, p. 1311-6
9. Brown D Jr, Binder GL, Gardner HL, Wells J (1980) "Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis." Obstet Gynecol, 56, p. 121-3
10. Lebherz TB, Ford LC, Kleinkopf V (1981) "A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis." Clin Ther, 3, p. 344-8
11. Stein GE, Christensen S, Mummaw N (1991) "Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis." DICP, 25, p. 582-5
12. Sawyer PR, Brogden RN, Pinder RM, Speight TM, Avery (1975) "Clotrimazole: a review of its antifungal activity and therapeutic efficacy." Drugs, 9, p. 424-47
Frequently asked questions
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Patient resources
- Clotrimazole topical drug information
- Clotrimazole vaginal
- Clotrimazole Cream, Ointment, and Solution
- Clotrimazole Vaginal Cream
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Professional resources
- Clotrimazole (Topical) monograph
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Further information
Clotrimazole topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
