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Clindamycin / tretinoin topical Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 1, 2023.

Applies to clindamycin/tretinoin topical: topical application gel/jelly.

Serious side effects

Along with its needed effects, clindamycin/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clindamycin / tretinoin topical:

More common

Less common

Other side effects

Some side effects of clindamycin / tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to clindamycin / tretinoin topical: topical gel.

General

The most commonly reported side effects were erythema, dryness, and itching.[Ref]

Dermatologic

Very common (10% or more): Erythema, dryness

Common (1% to 10%): Sunburn, scaling, burning, itching

Uncommon (0.1% to 1%): Acne, dry skin, seborrhea, photosensitivity reaction, pruritus, rash, exfoliative rash, skin exfoliation

Rare (less than 0.1%): Dermatitis, herpes simplex, rash macular, skin bleeding, skin depigmentation, skin irritation[Ref]

Local

Common (1% to 10%): Application site dryness, application site irritation, application site exfoliation, application site erythema, application site pruritus, application site dermatitis

Uncommon (0.1% to 1%): Application site reaction, application site burning

Rare (less than 0.1%): Application site swelling, application site erosion, application site discoloration, application site desquamation[Ref]

Other

Rare (less than 0.1%): Feeling hot, pain[Ref]

Endocrine

Rare (less than 0.1%): Hypothyroidism[Ref]

Gastrointestinal

Rare (less than 0.1%): Gastroenteritis, nausea[Ref]

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity[Ref]

Nervous system

Rare (less than 0.1%): Headache[Ref]

Ocular

Rare (less than 0.1%): Eye irritation[Ref]

References

1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. Ziana (clindamycin-tretinoin topical). Medicis Pharmaceutical Corporation. 2006.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.