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Cleanse & Treat Plus Side Effects

Generic Name: benzoyl peroxide / salicylic acid topical

Note: This page contains information about the side effects of benzoyl peroxide / salicylic acid topical. Some of the dosage forms included on this document may not apply to the brand name Cleanse & Treat Plus.

For the Consumer

Applies to benzoyl peroxide / salicylic acid topical: capsules, pads

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; feeling of warmth; mild irritation, itching, peeling, redness, or stinging.

Seek medical attention right away if any of these SEVERE side effects occur while taking benzoyl peroxide / salicylic acid topical:

Severe allergic reactions (rash; hives; itching; dizziness; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive burning, itching, irritation, peeling, redness, or tenderness of your skin; extreme dryness; swelling.

For Healthcare Professionals

Applies to benzoyl peroxide / salicylic acid topical: topical pad


Excessive drying has been associated with skin peeling, irritation, erythema, and possible edema.[Ref]

Dermatologic side effects have included allergic contact dermatitis and excessive drying (4%).[Ref]


Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported.[Ref]

Nervous system

Nervous system side effects including dizziness, loss of hearing, tinnitus, and lethargy have been reported.[Ref]


Respiratory side effects including hyperpnea have been reported.[Ref]


1. "Product Information. Inova (benzoyl peroxide topical)." JSJ Pharmaceuticals, Doylestown, PA.

Not all side effects for Cleanse & Treat Plus may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Cleanse & Treat Plus (benzoyl peroxide / salicylic acid topical)

Consumer resources

Other brands: Inova 8/2, Inova 4/1, Cleanse & Treat

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.