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Citric acid / magnesium oxide / sodium picosulfate Side Effects

For the Consumer

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for solution

In addition to its needed effects, some unwanted effects may be caused by citric acid / magnesium oxide / sodium picosulfate. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking citric acid / magnesium oxide / sodium picosulfate:

Incidence not known:
  • Bloody stools
  • confusion
  • convulsions
  • decreased urine output
  • dizziness or fainting
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fever
  • headache
  • hives, itching or skin rash
  • jerking or shaking of the muscles
  • joint pain, stiffness, or swelling
  • muscle pain or cramps
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red or purple spots on the skin
  • shortness of breath
  • swelling of the eyelids, face, lips, ankles, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for reconstitution


Cardiovascular side effects have included headache (up to 8%).[Ref]


Gastrointestinal side effects have included nausea (up to 11%). A certain amount of abdominal bloating, distention, pain/cramping, and watery diarrhea are expected as a consequence of the mechanism of action of citric acid/Mg oxide/Na picosulfate and should be expected. Gastrointestinal side effects reported postmarketing have included abdominal pain, diarrhea, fecal incontinence, and proctalgia. There have been isolated reports of reversible aphthoid ileal ulcers.[Ref]


Hypersensitivity side effects reported postmarketing have included rash, urticaria, and purpura.[Ref]


Metabolic side effects have included electrolyte imbalances including hypokalemia, hyponatremia, and hypermagnesemia.[Ref]


1. "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

Not all side effects for citric acid / magnesium oxide / sodium picosulfate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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