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Citric acid / magnesium oxide / sodium picosulfate Side Effects

For the Consumer

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for solution, oral solution

Along with its needed effects, citric acid/magnesium oxide/sodium picosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking citric acid / magnesium oxide / sodium picosulfate:

Incidence not known
  • Bleeding of the rectum
  • bloody stools
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness or fainting
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fever
  • headache
  • hives, itching, skin rash
  • increased thirst
  • jerking or shaking of the muscles
  • joint pain, stiffness, or swelling
  • loss of bowel control
  • loss of consciousness
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red or purple spots on the skin
  • seizures
  • stomach pain and tenderness
  • swelling of the eyelids, face, lips, ankles, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
  • vomiting

Some side effects of citric acid / magnesium oxide / sodium picosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Pain in the rectum

For Healthcare Professionals

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for reconstitution, oral solution


Cardiovascular side effects have included headache (up to 8%).[Ref]


Gastrointestinal side effects have included nausea (up to 11%). A certain amount of abdominal bloating, distention, pain/cramping, and watery diarrhea are expected as a consequence of the mechanism of action of citric acid/Mg oxide/Na picosulfate and should be expected. Gastrointestinal side effects reported postmarketing have included abdominal pain, diarrhea, fecal incontinence, and proctalgia. There have been isolated reports of reversible aphthoid ileal ulcers.[Ref]


Hypersensitivity side effects reported postmarketing have included rash, urticaria, and purpura.[Ref]


Metabolic side effects have included electrolyte imbalances including hypokalemia, hyponatremia, and hypermagnesemia.[Ref]


1. "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

Some side effects of citric acid / magnesium oxide / sodium picosulfate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.