Skip to Content

Chlorpheniramine / dihydrocodeine / phenylephrine Side Effects

Applies to chlorpheniramine/dihydrocodeine/phenylephrine: oral liquid, oral syrup

General

General side effects including light-headedness, dizziness, drowsiness, headache, fatigue, and sedation have been among the most frequently reported with opioid use. Confusion, abdominal pain, lassitude, giddiness, increased irritability or excitement (especially in children) have been reported. Hallucinations, severe narcosis, and vivid dreams have been reported rarely.[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and constipation have been among the most frequently reported with opioid use. Diarrhea, dry mouth, indigestion, anorexia, spasm of biliary tract have been reported.[Ref]

Dermatologic

Dermatologic side effects including sweating, pruritus, and skin reactions have been among the most frequently reported with opioid use. Flushing has been reported.[Ref]

Other

Symptoms of dihydrocodeine withdrawal consist of irritability, restlessness, insomnia, diaphoresis, anxiety, and palpitations.[Ref]

Other side effects of dihydrocodeine have included psychological dependence, physical dependence, and tolerance have been reported to develop upon repeated administration.[Ref]

Renal

Renal side effects including granulomatous interstitial nephritis and acute renal failure have been reported rarely during dihydrocodeine administration.[Ref]

Cardiovascular

Cardiovascular side effects including orthostatic hypotension and cardiac palpitations have been reported.[Ref]

Respiratory

Respiratory side effects including respiratory depression have been reported.[Ref]

Ocular

Ocular side effects including miosis and blurred vision have been reported.[Ref]

Genitourinary

Genitourinary side effects including urinary retention have been reported.[Ref]

Hypersensitivity

Hypersensitivity side effects including anaphylactoid reactions have been reported rarely.[Ref]

References

1. "Product Information. Pancof-PD (chlorpheniramine / dihydrocodeine / phenylephrine)." Pamlab LLC, Mandeville, LA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about chlorpheniramine/dihydrocodeine/phenylephrine

Professional resources

Related treatment guides

Hide