Guaifenesin and pseudoephedrine
Generic Name: guaifenesin and pseudoephedrine (gwye FEN e sin, SOO doe ee FED rin)
Brand Name: Ambifed-G, Despec-SR, Entex T, Maxifed, Mucinex D, Mucinex D Max Strength, Poly-Vent IR, Respaire-30, Robitussin Severe Congestion, Sinutab Non Drying, Triaminic Softchews Chest Congestion, Tusnel Pediatric Drops, ...show all 150 brand namesGuaimax-D, Anatuss LA, Entex PSE, Touro LA, Medent, Fenex-PSE, Nalex, Syn-Rx, Rymed (obsolete), Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr., G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guaibid D Pediatric, Guaifed-PD, Pseudocot-G, Zephrex, Nasatab LA, Eudal SR, Medent LD, Sudal 60/500, Maxifed-G (obsolete), Tuss-LA, Stamoist E, V-Dec-M, Deconsal L.A., D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Guiatex II, Guiadrine II SR, Defen-LA, Respa-1st, Decongest II, Desal II, Deco-D, GP 500, Maxifed (obsolete), Guaifed-PSE, Pan-Mist LA, Abletex-PSE, Guiadrine PSE 120, Duratuss (obsolete), Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Zephrex LA, Ru Tuss DE, Robitussin PE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Congestac, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Duratuss GP (obsolete), Aquatab D (obsolete1), Guaifenex GP, Dynex, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, Triaminic Chest Congestion (obsolete), Coldmist, Aquatab D Dose Pack, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Levall G, Guaifenex PSE 80, Pseudatex, Touro LA-LD, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Ambi 60/580, Ambi 80/780, Ambi 60/1000, Pseudo GG TR, Ru-Tuss Jr., ExeFen, SudaTex-G, Medent-LDI, Ambifed, Tenar PSE, ExeFen-IR, Mucus Relief D
What is guaifenesin and pseudoephedrine?
Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Guaifenesin and pseudoephedrine is a combination medicine used to treat stuffy nose and sinus congestion, and to reduce chest congestion caused by the common cold or flu.
Guaifenesin and pseudoephedrine may also be used for purposes not listed in this medication guide.
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Before taking this medicine
You should not use guaifenesin and pseudoephedrine if you are allergic to it.
Do not use guaifenesin and pseudoephedrine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Ask a doctor or pharmacist if it is safe for you to take this medication if you have:
overactive thyroid; or
enlarged prostate or problems with urination.
It is not known if this medication may be harmful to an unborn baby. Do not use guaifenesin and pseudoephedrine without medical advice if you are pregnant.
Guaifenesin and pseudoephedrine may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use this medicine without medical advice if you are breast-feeding a baby.
Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).
How should I take guaifenesin and pseudoephedrine?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole.
The chewable tablet must be chewed before you swallow it.
Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since guaifenesin and pseudoephedrine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking guaifenesin and pseudoephedrine?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Drinking alcohol with guaifenesin and pseudoephedrine can cause side effects.
Ask a doctor or pharmacist before using any other cough, cold, or allergy medicine. Guaifenesin and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug.
Guaifenesin and pseudoephedrine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using guaifenesin and pseudoephedrine and call your doctor at once if you have:
fast, pounding, or uneven heartbeat; or
severe anxiety or nervousness.
Common side effects may include:
dry mouth, nose, or throat;
feeling excited or restless (especially in children);
sleep problems (insomnia); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Guaifenesin and pseudoephedrine dosing information
Usual Adult Dose for Cough and Nasal Congestion:
Immediate release tablets: 1 tablet (30 mg to 45 mg pseudoephedrine) orally up to 4 times a day.
Immediate release syrup: 10 mL (30 mg to 90 mg pseudoephedrine) orally up to 4 times a day.
Immediate release capsule: 1 or 2 capsules (30 mg to 60 mg pseudoephedrine) every 4 to 6 hours, not to exceed 4 capsules in 24 hours.
Extended release tablets or capsules: 1 tablet or capsule (30 mg to 120 mg pseudoephedrine) orally every 12 hours.
Maximum is 240 mg pseudoephedrine or 2.4 g of guaifenesin/day.
Usual Pediatric Dose for Cough and Nasal Congestion:
3 years or older:
Immediate release tablet, capsule or syrup (15 mg to 60 mg pseudoephedrine) orally up to every 4 hours, not to exceed 4 mg/kg pseudoephedrine HCl or 12 mg/kg of guaifenesin/day.
guaifenesin-pseudoephedrine 50 mg-7.5 mg/mL pediatric drops:
2 years to under 6 years (11 to 21 kg): 2 mL every 4 to 6 hours, not to exceed 4 doses in 24 hours.
13 years or older:
1 extended release tablet or capsule (30 mg to 120 mg pseudoephedrine) every 12 hours, not to exceed 4 mg/kg pseudoephedrine HCl or 12 mg/kg of guaifenesin/day.
guaifenesin-pseudoephedrine 150 mg-30 mg oral capsule:
12 years or older: 1 or 2 capsules every 4 to 6 hours, not to exceed 8 capsules in 24 hours.
6 years to 11 years: 1 capsule every 4 to 6 hours, not to exceed 4 capsules in 24 hours.
What other drugs will affect guaifenesin and pseudoephedrine?
Ask a doctor or pharmacist before using guaifenesin and pseudoephedrine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.
Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking guaifenesin and pseudoephedrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 11.06.
More about guaifenesin/pseudoephedrine
- Guaifenesin/pseudoephedrine Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- 216 Reviews
- Drug class: upper respiratory combinations
- FDA Alerts (1)
- Guaifenesin and Pseudoephedrine Capsules and Tablets
- Guaifenesin and Pseudoephedrine Extended-Release Tablets
- Guaifenesin and Pseudoephedrine Liquid