CaroSpir Side Effects

Generic name: spironolactone

Medically reviewed by Drugs.com. Last updated on Oct 11, 2023.

Note: This document provides detailed information about CaroSpir Side Effects associated with spironolactone. Some dosage forms listed on this page may not apply specifically to the brand name CaroSpir.

Applies to spironolactone: oral suspension, oral tablet.

Serious side effects of CaroSpir

Along with its needed effects, spironolactone (the active ingredient contained in CaroSpir) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking spironolactone:

Incidence not known

• bleeding gums
• bloody or black, tarry stools
• bloody urine
• blurred vision
• breast pain
• chest pain
• clay-colored stools
• clear or bloody discharge from the nipple
• cloudy urine
• confusion
• constipation
• cough
• dark urine
• decrease in urine output or decrease in urine-concentrating ability
• diarrhea
• difficulty with swallowing
• dimpling of the breast skin
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• fast or irregular heartbeat
• fever with or without chills
• general feeling of tiredness or weakness
• headache
• heartburn
• hives, itching, or skin rash
• hoarseness
• increased thirst
• indigestion
• inverted nipple
• loss of appetite
• loss of consciousness
• lower back or side pain
• lump in the breast or under the arm
• muscle pain or cramps
• muscle spasms or twitching
• nausea
• painful or difficult urination
• persistent crusting or scaling of the nipple
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness or swelling of the breast
• seizures
• severe stomach pain
• shakiness and unsteady walk
• sore on the skin of the breast that does not heal
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach cramping, burning, or tenderness
• swelling of the face, fingers, feet, ankles, or lower legs
• swollen, painful, or tender lymph glands in the neck, armpit, or groin
• tightness in the chest
• trembling
• troubled breathing
• unpleasant breath odor
• unsteadiness, trembling, or other problems with muscle control or coordination
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting
• vomiting of blood or material that looks like coffee grounds
• weight gain
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking spironolactone:

Symptoms of overdose

• irregular heartbeat
• nervousness
• numbness or tingling in the hands, feet, or lips
• rash with flat lesions or small raised lesions on the skin
• reddened skin
• weakness or heaviness of the legs

Other side effects of CaroSpir

Some side effects of spironolactone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• burning feeling in the chest or stomach
• decreased interest in sexual intercourse
• hair loss or thinning of the hair
• inability to have or keep an erection
• leg cramps
• loss in sexual ability, desire, drive, or performance
• pain in the nipples
• sores, welts, or blisters
• stomach upset
• swelling of the breasts or breast soreness in both females and males
• unusual dullness or feeling of sluggishness

For Healthcare Professionals

Applies to spironolactone: compounding powder, oral suspension, oral tablet.

General

The most common adverse effect was gynecomastia.^[Ref]

Endocrine

• Very common (10% or more): Gynecomastia (13%)
• Frequency not reported: Breast disorders in women, slight androgenic effects, breast tenderness in women, voice deepening in women, breast pain^[Ref]

Metabolic

• Common (1% to 10%): Hyperkalemia, hyponatremia
• Uncommon (0.1% to 1%): Acidosis in patients with liver problems
• Rare (less than 0.1%): Dehydration, porphyria, hyperuricemia
• Frequency not reported: Reversible hyperchloremic metabolic acidosis in patients with decompensated hepatic cirrhosis, electrolyte disturbances^[Ref]

Genitourinary

• Common (1% to 10%): Changes in vaginal secretions, amenorrhea, postmenopausal bleeding
• Frequency not reported: Reproductive system disorders, erectile dysfunction, impotence, menstrual disorders^[Ref]

Nervous system

• Common (1% to 10%): Lethargy in patients with cirrhosis, paresthesia
• Rare (less than 0.1%): Paralysis, paraplegia of the limbs due to hyperkalemia
• Frequency not reported: Headache, drowsiness, dizziness, ataxia^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting
• Very rare (less than 0.01%): Gastric inflammation, gastric ulcers, intestinal hemorrhage, cramps
• Frequency not reported: Digestive system disorders, diarrhea, indigestion, gastric bleeding^[Ref]

Psychiatric

• Common (1% to 10%): Libido reduced in women
• Uncommon (0.1% to 1%): Confusion
• Frequency not reported: Libido reduced in men^[Ref]

Oncologic

• Common (1% to 10%): Malaise
• Very rare (less than 0.01%): Breast cancer^[Ref]

Other

• Common (1% to 10%): Weakness
• Frequency not reported: Fatigue, fever^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, urticaria, erythema, chloasma, pruritus, exanthema
• Rare (less than 0.1%): Eczema
• Very rare (less than 0.01%): Alopecia, erythema annulare centrifugum, hypertrichosis
• Frequency not reported: Hirsutism, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS), maculopapular or erythematous cutaneous eruptions^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Muscle spasms, leg cramps
• Very rare (less than 0.01%): Systemic lupus erythematosus, osteomalacia^[Ref]

Renal

• Uncommon (0.1% to 1%): Serum creatinine elevated
• Rare (less than 0.1%): BUN increased
• Very rare (less than 0.01%): Acute renal failure
• Frequency not reported: Renal dysfunction^[Ref]

Hematologic

• Rare (less than 0.1%): Thrombocytopenia, eosinophilia, leukopenia
• Frequency not reported: Agranulocytosis^[Ref]

Immunologic

• Rare (less than 0.1%): Hypersensitivity
• Frequency not reported: Anaphylactic reactions^[Ref]

Cardiovascular

• Very rare (less than 0.01%): Vasculitis
• Frequency not reported: Mild hypotension^[Ref]

Hepatic

• Very rare (less than 0.01%): Hepatitis
• Frequency not reported: Mixed cholestatic/hepatocellular toxicity^[Ref]

Frequently asked questions

• What is the strength of CaroSpir (spironolactone) oral suspension?
• Winlevi vs Spironolactone: How do they compare?

Further information

CaroSpir side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer