Cangrelor Side Effects

For the Consumer

Applies to cangrelor: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by cangrelor. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking cangrelor, check with your doctor or nurse immediately:

• Abdominal or stomach pain or swelling
• back pain
• black, tarry stools
• blood in the eyes
• blood in the urine
• bruising or purple areas on the skin
• coughing up blood
• decreased alertness
• dizziness
• headache
• joint pain or swelling
• nosebleeds

• Difficult or labored breathing
• tightness in the chest

• Cough
• difficulty with swallowing
• fast heartbeat
• hives, itching, or rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• noisy breathing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• unusual tiredness or weakness

For Healthcare Professionals

Applies to cangrelor: intravenous powder for injection

General

The most common adverse reaction was bleeding.^[Ref]

Cardiovascular

Very common (10% or more): Any Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding (15.5%), mild GUSTO bleeding (14.9%)
Uncommon (0.1% to 1%): Severe/life-threatening GUSTO bleeding, moderate GUSTO bleeding, any Thrombolysis in Myocardial Infarction (TIMI) bleeding, major TIMI bleeding, minor TIMI bleeding
Frequency not reported: Coronary artery dissection, coronary artery perforation^[Ref]

Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding definitions:
-Severe/life-threatening GUSTO bleeding: Intracranial hemorrhage or bleeding resulting in substantial hemodynamic compromise requiring treatment.
-Moderate GUSTO bleeding: Bleeding requiring blood transfusion but not resulting in hemodynamic compromise.
-Mild GUSTO bleeding: All other bleeding not included in severe or moderate.

Thrombolysis in Myocardial Infarction (TIMI) bleeding definitions:
-Major TIMI bleeding: Any intracranial hemorrhage or any overt bleeding associated with a reduction in hemoglobin of at least 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 15% or more).
-Minor TIMI bleeding: Any overt sign of bleeding (including observation by imaging techniques) associated with a reduction in hemoglobin of 3 to less than 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 9% to less than 15%).^[Ref]

Respiratory

Common (1% to 10%): Dyspnea
Frequency not reported: Bronchospasm, stridor^[Ref]

Renal

Common (1% to 10%): Worsening renal function in patients with CrCl less than 30 mL/min^[Ref]

Immunologic

Rare (less than 0.1%): Hypersensitivity
Frequency not reported: Anaphylactic reactions, anaphylactic shock^[Ref]

Dermatologic

Frequency not reported: Angioedema^[Ref]

Not all side effects for cangrelor may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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