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Cangrelor Dosage

Applies to the following strengths: 50 mg

Usual Adult Dose for Percutaneous Coronary Intervention

30 mcg/kg IV bolus prior to percutaneous coronary intervention (PCI) followed immediately by 4 mcg/kg/min IV infusion for at least 2 hours or for the duration of the PCI, whichever is longer

Use: Adjunct to PCI to reduce the risk of periprocedural myocardial infarction, repeat coronary revascularization, and stent thrombosis in patients who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Transitioning patients to oral P2Y12 therapy:
-Ticagrelor: 180 mg orally at any time during cangrelor infusion or immediately after cangrelor discontinuation.
-Prasugrel: 60 mg orally immediately after discontinuation of cangrelor. Do not administer prasugrel prior to discontinuation of cangrelor.
-Clopidogrel: 600 mg orally immediately after discontinuation of cangrelor. Do not administer clopidogrel prior to discontinuation of cangrelor.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Administer via a dedicated IV line.
-Administer bolus rapidly (less than 1 minute), from the diluted bag via manual IV push or pump.
-Ensure bolus is completely administered before the start of percutaneous coronary intervention (PCI).

Reconstitution/preparation techniques: Manufacturer product information should be consulted.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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