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Canakinumab Side Effects

For the Consumer

Applies to canakinumab: subcutaneous powder for solution

In addition to its needed effects, some unwanted effects may be caused by canakinumab. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking canakinumab, check with your doctor or nurse immediately:

More common:
  • Body aches or pain
  • chills
  • congestion
  • cough
  • diarrhea
  • dryness or soreness of the throat
  • fever
  • headache
  • hoarseness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • shivering
  • shortness of breath
  • sneezing
  • stuffy or runny nose
  • sweating
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble sleeping
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
  • vomiting

Minor Side Effects

Some of the side effects that can occur with canakinumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • increased weight
  • muscle or bone pain
  • sensation of spinning
  • weakness

For Healthcare Professionals

Applies to canakinumab: subcutaneous powder for injection

Gastrointestinal

Very common (10% or more): Diarrhea (20%), nausea (14%), gastroenteritis, tonsillitis, upper abdominal pain, gastroesophageal reflux disease[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection[Ref]

Hematologic

Very common (10% or more): Leukopenia
Frequency not reported: Hemoglobin increased, decreased white blood cells, decreased neutrophils, decreased platelets[Ref]

Hepatic

Rare (less than 0.1%): Elevated transaminases
Frequency not reported: Elevated serum bilirubin[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (unspecified)[Ref]

Immunologic

Very common (10% or more): Influenza (17%), viral infection (13%)[Ref]

Local

Very common (10% or more): Injection site reaction[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (11%), arthralgia
Common (1% to 10%): Back pain[Ref]

Nervous system

Very common (10% or more): Headache (14%), dizziness/vertigo (11%)[Ref]

Other

Very common (10% or more): Ear infection
Common (1% to 10%): Fatigue/asthenia[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis (34%), rhinitis (17%), bronchitis (11%), pneumonia, sinusitis, rhinitis, pharyngitis, upper respiratory tract infection[Ref]

Dermatologic

Very common (10% or more): Cellulitis[Ref]

Metabolic

Very common (10% or more): Weight gain (11%)[Ref]

Renal

Very common (10% or more): Creatinine clearance decreased, proteinuria[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Ilaris (canakinumab)." Novartis Pharmaceuticals, East Hanover, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for canakinumab may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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