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Busodium Side Effects

Generic Name: butabarbital

Note: This document contains side effect information about butabarbital. Some of the dosage forms listed on this page may not apply to the brand name Busodium.

For the Consumer

Applies to butabarbital: oral elixir, oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Shortness of breath.
  • Very upset stomach or throwing up.
  • Change in balance.
  • Slurred speech.
  • Worse trouble sleeping.
  • Feeling confused.
  • Change in how you act.
  • Bad dreams.
  • Feeling nervous and excitable.
  • Hallucinations (seeing or hearing things that are not there).
  • Not able to sleep.
  • Anxiety.
  • Very bad dizziness or passing out.
  • Slow heartbeat.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Dizziness.
  • Feeling sleepy the next day.
  • Upset stomach or throwing up.
  • Hard stools (constipation).
  • Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

For Healthcare Professionals

Applies to butabarbital: oral elixir, oral tablet

Nervous system

Nervous system side effects have included somnolence, headache, confusion, hyperkinesias, ataxia, and dizziness.[Ref]


Cardiovascular side effects have included bradycardia, hypotension, and syncope.[Ref]


Gastrointestinal side effects have included nausea, vomiting, and constipation.[Ref]


Hypersensitivity reactions have included angioedema, skin rash, and exfoliative dermatitis.[Ref]


Oncologic side effects have included a possible increased frequency of malignancy (particularly liver cancer and brain tumors) following use of phenobarbital and other barbiturates.[Ref]


Other side effects have included physical and psychological dependence. Withdrawal symptoms have been reported when butabarbital (the active ingredient contained in Busodium) therapy has been discontinued suddenly.[Ref]


Psychiatric side effects have included agitation, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, and abnormal thinking.[Ref]


Respiratory side effects have included hypoventilation and apnea.[Ref]


1. "Product Information. Butisol Sodium (butabarbital)." Meda Pharmaceuticals, Somerset, NJ.

Some side effects of Busodium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.