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Brovana Side Effects

Generic Name: arformoterol

Note: This document contains side effect information about arformoterol. Some of the dosage forms listed on this page may not apply to the brand name Brovana.

For the Consumer

Applies to arformoterol: inhalation solution

Along with its needed effects, arformoterol (the active ingredient contained in Brovana) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking arformoterol:

More common
  • Back pain
  • chest pain
  • diarrhea
  • pain
Less common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • chills
  • cough
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • leg cramps
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • rapid weight gain
  • rash
  • shivering
  • shortness of breath
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest
  • tingling of the hands or feet
  • trouble with sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking arformoterol:

Symptoms of overdose
  • Arm, back, or jaw pain
  • blurred vision
  • chest discomfort
  • chest tightness or heaviness
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • increased thirst
  • mood changes
  • muscle pain or cramps
  • muscle tremors
  • nervousness
  • no blood pressure or pulse
  • numbness or tingling in the hands, feet, or lips
  • pounding in the ears
  • rapid, deep breathing
  • restlessness
  • slow heartbeat
  • stomach cramps
  • stopping of the heart
  • tremor
  • unconsciousness

For Healthcare Professionals

Applies to arformoterol: inhalation solution


Two double-blind, placebo-controlled clinical trials showed a decreased or comparable incidence of COPD exacerbations when compared to placebo. COPD exacerbations occurred at a rate of 12.1% for those patients receiving the drug and 15.1% for those patients receiving placebo.[Ref]

Common (1% to 10%): Dyspnea, sinusitis, flu syndrome, pulmonary and chest congestion
Frequency not reported (Less than 2%): Respiratory disorder, voice alteration[Ref]


Common (1% to 10%): Chest pain, peripheral edema
Frequency not reported (Less than 2%): Arteriosclerosis, atrial flutter, AV block, congestive heart failure, heart block, myocardial infarct, QT interval prolongation, supraventricular tachycardia, inverted T-wave[Ref]

Two double-blind, placebo-controlled clinical trials showed a decreased or comparable incidence of cardiovascular events. Frequency of all cardiovascular events was 6.9% in those using the drug and 13.3% in the placebo group. No frequently occurring, defined as 1% or greater than placebo, cardiovascular events were associated.[Ref]


Common (1% to 10%): Rash
Frequency not reported (Less than 2%): Dry skin, herpes simplex, herpes zoster, skin discoloration, skin hypertrophy[Ref]


Common (1% to 10%): Diarrhea
Frequency not reported (Less than 2%): Constipation, gastritis, melena, oral moniliasis, periodontal abscess, rectal hemorrhage[Ref]


Common (1% to 10%): Back pain, leg cramps
Frequency not reported (Less than 2%): Neck rigidity, pelvic pain, arthralgia, arthritis, rheumatoid arthritis, bone disorder, tendinous contracture[Ref]


Frequency not reported (Less than 2%): Retroperitoneal hemorrhage


Frequency not reported (Less than 2%): Allergic reaction


Frequency not reported (Less than 2%): Injection site pain


Frequency not reported (Less than 2%): Dehydration, edema, glucose tolerance decreased, gout, hyperglycemia, hyperlipidemia, hypoglycemia, hypokalemia

Nervous system

Frequency not reported (Less than 2%): Agitation, cerebral infarct, circumoral paresthesia, hypokinesia, somnolence, tremor, paralysis


Frequency not reported (Less than 2%): Abnormal vision, glaucoma


Frequency not reported (Less than 2%): Neoplasm, carcinoma of the lung, breast neoplasm


Common (1% to 10%): Pain
Frequency not reported (Less than 2%): Digitalis intoxication, abscess, fever, hernia


Frequency not reported (Less than 2%): Calcium crystalluria, cystitis, glycosuria, hematuria, kidney calculus, nocturia, PSA increase, pyuria, urinary tract disorder, urine abnormality


1. "Product Information. Brovana (arformoterol)." Sepracor Inc, Marlborough, MA.

Some side effects of Brovana may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.