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Brigatinib Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 4, 2020.

In Summary

Commonly reported side effects of brigatinib include: asthenia, blurred vision, cough, decreased visual acuity, diplopia, dyspnea, hyperglycemia, hypertension, increased amylase, increased creatine phosphokinase in blood specimen, increased serum lipase, myalgia, and visual disturbance. Other side effects include: interstitial pulmonary disease, pneumonitis, and bradycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brigatinib: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, brigatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brigatinib:

More common

  • Back pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or tightness
  • chills
  • confusion
  • cough
  • decreased appetite
  • difficulty in moving
  • dizziness
  • dry mouth
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • hoarseness
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle pain, tenderness, or weakness
  • nausea
  • nervousness
  • pain in the arms or legs
  • painful or difficult urination
  • pale skin
  • pounding in the ears
  • skin rash or itching
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stomach pain or tenderness
  • sweating
  • swollen joints
  • thickening of bronchial secretions
  • trouble breathing
  • troubled breathing with exertion
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • weakness in the arms, hands, legs, or feet

Less common

  • General feeling of discomfort or illness
  • thickening of bronchial secretions

Rare

  • Fast heartbeat

Side effects not requiring immediate medical attention

Some side effects of brigatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • diarrhea
  • difficulty having a bowel movement
  • trouble sleeping

For Healthcare Professionals

Applies to brigatinib: oral tablet

General

-The most common adverse reactions (25% or more) were nausea, diarrhea, fatigue, cough, and headache.

-Serious adverse reactions occurred in 38% to 40% of patients; fatal cases were reported in 3.7% of patients and consisted of pneumonia (2 patients), sudden death, dyspnea, respiratory failure, pulmonary embolism, bacterial meningitis, and urosepsis (1 patient each).[Ref]

Hepatic

Very common (10% or more): Increased AST (65%), increased ALT (40%), increased alkaline phosphatase (29%)[Ref]

Endocrine

Very common (10% or more): Hyperglycemia (49%)[Ref]

Musculoskeletal

Very common (10% or more): Increased creatine phosphokinase (48%), muscle spasms (17%), back pain (15%), myalgia/musculoskeletal pain (15%), arthralgia (14%), pain in extremity (11%)[Ref]

Gastrointestinal

Very common (10% or more): Increased lipase (45%), nausea (40%), increased amylase (39%), diarrhea (38%), vomiting (24%), constipation (19%), abdominal pain and distension/epigastric discomfort (17%)[Ref]

Hematologic

Very common (10% or more): Anemia (40%), lymphopenia (27%)[Ref]

Other

Very common (10% or more): Fatigue/asthenia (36%), pyrexia (14%)[Ref]

Respiratory

Very common (10% or more): Cough (34%), dyspnea/exertional dyspnea (27%)

Common (1% to 10%): interstitial lung disease/pneumonitis, hypoxia[Ref]

Nervous system

Very common (10% or more): Headache/sinus headache (28%), peripheral sensory neuropathy/paresthesia (13%)[Ref]

Dermatologic

Very common (10% or more): Rash (exfoliative, pruritic, pustular)/acneiform dermatitis (24%)[Ref]

Metabolic

Very common (10% or more): Decreased phosphorous (23%), decreased appetite (22%)[Ref]

Cardiovascular

Very common (10% or more): Prolonged activated partial thromboplastin time (22%), hypertension (21%)

Common (1% to 10%): Bradycardia[Ref]

Psychiatric

Very common (10% or more): Insomnia (11%)[Ref]

Ocular

Very common (10% or more): Visual disturbance (10%), pneumonia (10%)[Ref]

References

1. "Product Information. Alunbrig (brigatinib)." Ariad Pharmaceuticals Inc, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.