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Generic Name: brigatinib (bri GAT i nib)
Brand Names: Alunbrig

Medically reviewed by Last updated on Aug 14, 2019.

What is Alunbrig?

Alunbrig (brigatinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Alunbrig is used to treat non-small cell lung cancer that has spread to other parts of the body.

Alunbrig is for cancer that has a certain abnormal gene, and when treatment with other cancer medicine has not been successful.

Important information

Alunbrig can cause serious side effects such as lung problems, vision problems, high blood pressure, high blood sugar, very slow heartbeats, muscle damage, or pancreatitis.

Call your doctor at once if you have symptoms of any of these side effects, such as: severe headache, confusion, feeling light-headed, blurred vision, seeing flashes of light or "floaters" in your vision, increased thirst or urination, hunger, nausea, upper stomach pain spreading to your back, unexplained muscle pain or weakness, cough, trouble breathing, very slow heartbeats, or feeling like you might pass out.

Before taking this medicine

You should not use Alunbrig if you are allergic to brigatinib.

To make sure Alunbrig is safe for you, tell your doctor if you have ever had:

  • lung disease or breathing problems;

  • slow heartbeats;

  • high blood pressure;

  • diabetes or glucose intolerance;

  • pancreas problems; or

  • vision problems.

Alunbrig can harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine, whether you are a man or a woman. Men should use condoms. Alunbrig use by either parent may cause birth defects.

Use a barrier form of birth control (condom or diaphragm with spermicide). Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

If you are a woman, keep using birth control for at least 4 months after your last dose of Alunbrig. If you are a man, keep using condoms for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using brigatinib.

It is not known whether brigatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Alunbrig?

Take Alunbrig exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Alunbrig is usually taken once per day, with or without food.

Do not crush, chew, or break a tablet. Swallow the tablet whole.

If you vomit shortly after taking Alunbrig, do not take another dose. Stay on your regular schedule.

You should not stop using this medicine unless your doctor tells you to.

Store at room temperature away from moisture and heat.

Alunbrig dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

-Initial Dose: 90 mg orally once a day for the first 7 days
-Maintenance Dose: If initial dose is tolerated during the first 7 days, increase to 180 mg orally once a day.
-Duration of Therapy: Until disease progression or unacceptable toxicity

Use: Treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Alunbrig?

Grapefruit and grapefruit juice may interact with brigatinib and lead to unwanted side effects. Avoid the use of grapefruit products while taking Alunbrig.

This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Alunbrig side effects

Get emergency medical help if you have signs of an allergic reaction to Alunbrig: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • lung problems - cough, trouble breathing, chest pain, fever;

  • vision problems - blurred vision, double vision, increased sensitivity to light, seeing flashes of light or "floaters" in your vision;

  • high blood pressure - severe headache, pounding in your neck or ears, nosebleed;

  • high blood sugar - increased thirst, increased urination, hunger, nausea, fruity breath odor, weakness, confusion;

  • heart problems - very slow heartbeats, feeling like you might pass out;

  • muscle problems - unexplained muscle pain or weakness; or

  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea, weight loss.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Alunbrig side effects may include:

  • nausea, diarrhea;

  • cough;

  • headache; or

  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Alunbrig?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with brigatinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Alunbrig only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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