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Alunbrig Side Effects

Generic Name: brigatinib

Note: This document contains side effect information about brigatinib. Some of the dosage forms listed on this page may not apply to the brand name Alunbrig.

In Summary

Common side effects of Alunbrig include: asthenia, blurred vision, cough, decreased visual acuity, diplopia, dyspnea, hyperglycemia, hypertension, increased amylase, increased creatine phosphokinase, increased serum lipase, myalgia, and visual disturbance. Other side effects include: interstitial pulmonary disease, pneumonitis, and bradycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brigatinib: oral tablet

Along with its needed effects, brigatinib (the active ingredient contained in Alunbrig) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brigatinib:

More common
  • Abdominal or stomach pain or tenderness
  • back pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or tightness
  • chills
  • confusion
  • cough
  • decreased appetite
  • difficulty in moving
  • dizziness
  • fever
  • flushed, dry skin
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain
  • loss of appetite
  • muscle pain, tenderness, or weakness
  • nausea and vomiting
  • nervousness
  • pain in the arms or legs
  • pounding in the ears
  • skin rash or itching
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • swollen joints
  • thickening of bronchial secretions
  • trouble breathing
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet

Some side effects of brigatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Blurred vision or changes in vision
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • trouble sleeping

For Healthcare Professionals

Applies to brigatinib: oral tablet

General

-The most common adverse reactions (25% or more) were nausea, diarrhea, fatigue, cough, and headache.
-Serious adverse reactions occurred in 38% to 40% of patients; fatal cases were reported in 3.7% of patients and consisted of pneumonia (2 patients), sudden death, dyspnea, respiratory failure, pulmonary embolism, bacterial meningitis, and urosepsis (1 patient each).[Ref]

Hepatic

Very common (10% or more): Increased AST (65%), increased ALT (40%), increased alkaline phosphatase (29%)[Ref]

Endocrine

Very common (10% or more): Hyperglycemia (49%)[Ref]

Musculoskeletal

Very common (10% or more): Increased creatine phosphokinase (48%), muscle spasms (17%), back pain (15%), myalgia/musculoskeletal pain (15%), arthralgia (14%), pain in extremity (11%)[Ref]

Gastrointestinal

Very common (10% or more): Increased lipase (45%), nausea (40%), increased amylase (39%), diarrhea (38%), vomiting (24%), constipation (19%), abdominal pain and distension/epigastric discomfort (17%)[Ref]

Hematologic

Very common (10% or more): Anemia (40%), lymphopenia (27%)[Ref]

Other

Very common (10% or more): Fatigue/asthenia (36%), pyrexia (14%)[Ref]

Respiratory

Very common (10% or more): Cough (34%), dyspnea/exertional dyspnea (27%)
Common (1% to 10%): interstitial lung disease/pneumonitis, hypoxia[Ref]

Nervous system

Very common (10% or more): Headache/sinus headache (28%), peripheral sensory neuropathy/paresthesia (13%)[Ref]

Dermatologic

Very common (10% or more): Rash (exfoliative, pruritic, pustular)/acneiform dermatitis (24%)[Ref]

Metabolic

Very common (10% or more): Decreased phosphorous (23%), decreased appetite (22%)[Ref]

Cardiovascular

Very common (10% or more): Prolonged activated partial thromboplastin time (22%), hypertension (21%)
Common (1% to 10%): Bradycardia[Ref]

Psychiatric

Very common (10% or more): Insomnia (11%)[Ref]

Ocular

Very common (10% or more): Visual disturbance (10%), pneumonia (10%)[Ref]

References

1. "Product Information. Alunbrig (brigatinib)." Ariad Pharmaceuticals Inc, Cambridge, MA.

Some side effects of Alunbrig may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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