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Benzoyl peroxide / tretinoin topical Side Effects

Medically reviewed by Last updated on Apr 7, 2023.

Applies to benzoyl peroxide/tretinoin topical: topical application cream.

Serious side effects

Along with its needed effects, benzoyl peroxide/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benzoyl peroxide / tretinoin topical:

More common

Incidence not known

For Healthcare Professionals

Applies to benzoyl peroxide / tretinoin topical: topical cream.


Postmarketing reports: Anaphylaxis, angioedema, and urticaria[Ref]


Very common (10% or more): Application site pain (10.6%)

Common (1% to 10%): Application Site Dryness, application site exfoliation, application site erythema, application site dermatitis, application site pruritus, application site irritation[Ref]


1. Product Information. Twyneo (benzoyl peroxide-tretinoin topical). Sol-Gel Technologies Inc. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.