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Belzutifan Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 17, 2022.

Applies to belzutifan: oral tablet.

Warning

Oral route (Tablet)

Warning: Embryo-fetal toxicityExposure to belzutifan during pregnancy can cause embryo-fetal harm.Verify pregnancy status prior to the initiation of belzutifan.Advise patients of these risks and the need for effective non-hormonal contraception. Belzutifan can render some hormonal contraceptives ineffective.

Serious side effects of Belzutifan

Along with its needed effects, belzutifan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking belzutifan:

More common

  • Blurred vision
  • change in vision
  • chest tightness
  • confusion
  • cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • headache
  • hives, itching, skin rash
  • nervousness
  • pale skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Other side effects of Belzutifan

Some side effects of belzutifan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills
  • constipation
  • difficulty in moving
  • ear congestion
  • fever
  • loss of voice
  • muscle aches, cramps, pain, or stiffness
  • nausea
  • pain in the joints
  • sneezing
  • sore throat
  • stomach pain
  • stuffy or runny nose
  • swollen joints
  • weight increased

For Healthcare Professionals

Applies to belzutifan: oral tablet.

Hematologic

Very common (10% or more): Hemoglobin decreased (93%), anemia (90%), leukocytes decreased (11%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (18%), myalgia (16%)[Ref]

Ocular

Very common (10% or more): Visual impairment (e.g., vision blurred, central retinal vein occlusion and retinal detachment) (21%)[Ref]

Metabolic

Very common (10% or more): weight increased (12%)[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (e.g., bronchitis, sinusitis, upper respiratory tract infection, viral upper respiratory infection) (21%), dyspnea (20%)

Common (1% to 10%): Hypoxia[Ref]

Other

Very common (10% or more): Creatinine increased (64%), fatigue/asthenia (64%), glucose increased (34%), alanine aminotransferase (ALT) increased (20%), aspartate aminotransferase (AST) increased (16%), calcium decreased (10%), leukocytes decreased (11%)[Ref]

Nervous system

Very common (10% or more): Headache/migraine (39%), dizziness/vertigo (38%)[Ref]

Cardiovascular

Very common (10% or more): Hypertension (13%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (31%), constipation (13%), abdominal pain (e.g., abdominal discomfort, abdominal pain, abdominal pain upper, abdominal pain lower) (13%)[Ref]

References

1. "Product Information. Welireg (belzutifan)." Merck & Company Inc (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.