Articadent Side Effects
Generic name: articaine / epinephrine
Medically reviewed by Drugs.com. Last updated on Oct 11, 2024.
Note: This document provides detailed information about Articadent.
Applies to articaine / epinephrine: injection solution Side Effects associated with articaine / epinephrine. Some dosage forms listed on this page may not apply specifically to the brand name Articadent.
Applies to articaine / epinephrine: injection solution.
Precautions
It is very important that your dentist check your or your child's progress closely while receiving this medicine to see if it is working properly. Blood tests may be needed to check for any unwanted effects.
This medicine may increase your risk of having serious heart and blood vessel problems such as a heart attack, heart rhythm changes, or low blood pressure. Check with your doctor if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, dizziness, fainting, pounding, slow heartbeat, troubled breathing, or unusual tiredness or weakness.
Tell your dentist right away if you have the following symptoms with this medicine: anxiety, blurred vision, depression, drowsiness, lightheadedness, nausea or vomiting, numbness and tingling of the mouth or lips, restlessness, ringing in the ears, speech problems, or tremors.
This medicine may cause a rare, but serious blood problem called methemoglobinemia. The risk may be increased in children younger than 6 months of age, elderly patients, or patients with certain inborn defects. It is more likely to occur in patients receiving too much of the medicine, but can also occur with small amounts. Check with your doctor right away if you or your child has the following symptoms after receiving this medicine: pale, gray, or blue-colored skin, lips, or nails, confusion, headache, lightheadedness, fast heartbeat, or unusual tiredness or weakness.
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat after receiving this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Articadent
Along with its needed effects, articaine/epinephrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking articaine / epinephrine:
Less common side effects
- bleeding, redness, or swelling of the gums
- chills
- cough
- fast, irregular, pounding, or racing heartbeat or pulse
- fever
- hoarseness
- lower back or side pain
- mouth ulcers
- painful or difficult urination
- swelling of the face
- swelling or irritation of the mouth
Rare side effects
- blurred vision
- body aches or pain
- bruising
- congestion
- coughing up blood
- difficulty in breathing or swallowing
- difficulty opening the mouth
- dizziness
- dryness or soreness of the throat
- earache
- facial paralysis
- fainting
- headache, severe and throbbing
- increase in bone pain
- increased menstrual flow or vaginal bleeding
- increased sensitivity to pain or touch
- large, flat, blue or purplish patches in the skin
- lockjaw
- muscle spasm, especially of the neck and back
- nervousness
- nosebleeds
- paralysis
- pounding in the ears
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- redness or swelling in the ear
- runny or stuffy nose
- slow or fast heartbeat
- swelling of the tongue
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tingling in the hands and feet
- trouble in swallowing
- voice changes
Incidence not known
- bigger, dilated, or enlarged pupils (black part of the eye)
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings of the mouth
- chest pain or discomfort
- double vision
- drooping upper eyelids
- increased sensitivity of the eyes to light
- nausea
- pain in the shoulders, arms, jaw, or neck
- seeing double
- vomiting
Other side effects of Articadent
Some side effects of articaine / epinephrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- sleepiness
Rare side effects
- belching
- change in taste
- bad unusual or unpleasant (after) taste
- difficulty in moving
- dry mouth
- heartburn
- increased salivation
- indigestion
- itching skin
- joint pain or swelling
- lack or loss of strength
- muscle pain or stiffness
- nervousness
- pain or burning at the injection site
- runny nose
- sleepiness or unusual drowsiness
- sneezing
- stomach discomfort, upset, or pain
For healthcare professionals
Applies to articaine / epinephrine: injectable solution.
General adverse events
General side effects including sleepiness (1.1%), malaise, and asthenia have been reported.
Gastrointestinal
Gastrointestinal side effects including nausea and emesis (1.6%), gingivitis (1%), constipation, diarrhea, dyspepsia, glossitis, gum hemorrhage, mouth ulceration, nausea, stomatitis, tongue edema, tooth disorder, and vomiting have been reported.[Ref]
Musculoskeletal
Musculoskeletal side effects including trismus (1.6%), arthralgia, myalgia, back pain, and osteomyelitis have been reported.[Ref]
Other
Other side effects including pain (up to 13%), headache (up to 5%), positive blood aspiration into syringe (3.2%), swelling (2.7%), face edema (1%), infection (1%), neck pain, abdominal pain, ear pain, taste perversion, and accidental injury have been reported.[Ref]
Nervous system
Nervous system side effects including paresthesia (1%), numbness and tingling (1%), dizziness, dry mouth, facial paralysis, hyperesthesia, increased salivation, nervousness, neuropathy, paresthesia, somnolence, and exacerbation of Kearns-Sayre syndrome have been reported.
Persistent paresthesias of the lips, tongue, and oral tissues have been reported with use of articaine, with slow, incomplete, or no recovery. These events have been reported chiefly following nerve blocks in the mandible and have involved the trigeminal nerve and its branches.[Ref]
Cardiovascular
Cardiovascular side effects including palpitation (1.0%), hemorrhage, migraine, syncope, tachycardia, and elevated blood pressure have been reported.[Ref]
Respiratory
Respiratory side effects including pharyngitis, rhinitis, sinus pain, and sinus congestion have been reported.
Hematologic
Hematologic side effects including ecchymosis and lymphadenopathy have been reported.
Metabolic
Metabolic side effects including edema and thirst have been reported.
Local
Local side effects including injection site pain and a burning
sensation above the injection site have been reported.
Dermatologic
Dermatologic side effects including pruritus and skin disorder have been reported.
Genitourinary
Genitourinary side effects including dysmenorrhea have been reported.
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References
1. (2008) "Product Information. Septocaine (articaine-epinephrine)." Septodont Incorporated
More about Articadent (articaine / epinephrine)
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: local injectable anesthetics
Patient resources
Other brands
Septocaine, Orabloc, Ultacan, Ultacan Forte
Professional resources
Other brands
Septocaine, Orabloc, Ultacan, Zorcaine
Related treatment guides
Further information
Articadent side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.