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Anturane Side Effects

Generic Name: sulfinpyrazone

Note: This page contains information about the side effects of sulfinpyrazone. Some of the dosage forms included on this document may not apply to the brand name Anturane.

For the Consumer

Applies to sulfinpyrazone: oral capsule, oral tablet

In addition to its needed effects, some unwanted effects may be caused by sulfinpyrazone (the active ingredient contained in Anturane). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking sulfinpyrazone:

Rare
  • Shortness of breath, troubled breathing, tightness in chest, and/or wheezing
  • sores, ulcers, or white spots on lips or in mouth
  • sore throat and fever with or without chills
  • swollen and/or painful glands
  • unusual bleeding or bruising
Symptoms of overdose:
  • Clumsiness or unsteadiness
  • convulsions (seizures)
  • diarrhea
  • nausea or vomiting (severe or continuing)
  • stomach pain (severe or continuing)
  • difficulty in breathing

Severity: Moderate

If any of the following side effects occur while taking sulfinpyrazone, check with your doctor or nurse as soon as possible:

More common:
  • Lower back and/or side pain
  • painful urination (possibly with blood)
Less common:
  • Skin rash
Rare
  • Bloody or black, tarry stools
  • fever
  • increased blood pressure
  • pinpoint red spots on skin
  • sudden decrease in amount of urine
  • swelling of face, fingers, feet, and/or lower legs
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain

Minor Side Effects

Some of the side effects that can occur with sulfinpyrazone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Joint pain, redness, and/or swelling
  • nausea or vomiting
  • stomach pain

For Healthcare Professionals

Applies to sulfinpyrazone: oral capsule, oral tablet

Gastrointestinal

Gastrointestinal symptoms have been the most frequently reported side effects. Peptic ulcer disease may be exacerbated or reactivated.[Ref]

Hematologic

Hematologic side effects including anemia, leukopenia, agranulocytosis, thrombocytopenia, and aplastic anemia have occurred. Two cases of leukemia following chronic sulfinpyrazone (the active ingredient contained in Anturane) therapy have been reported. Concomitant drug therapy was also reported and a causal relationship with sulfinpyrazone has not been established.[Ref]

Dermatologic

Dermatologic side effects have been limited to rash.[Ref]

Renal

Renal failure has been reported. Suggested mechanisms have included hypersensitivity induced interstitial nephritis, tubular-interstitial damage due to precipitation of urinary uric acid crystals, and inhibition of renal prostaglandin synthesis. Urolithiasis and renal colic may occur following initiation of therapy. Adequate fluid intake and urinary alkalinization are recommended.[Ref]

Musculoskeletal

Mobilization of urates during initiation of therapy has resulted in musculoskeletal symptoms of acute gouty arthritis.[Ref]

References

1. Mattingly D, Bradley M, Selley PJ "Hazards of sulphinpyrazone." Br Med J 2 (1978): 1786-7

2. "Product Information. Anturane (sulfinpyrazone)." Novartis Pharmaceuticals, East Hanover, NJ.

3. Braun J "Abnormalities of urinary sediment and renal failure following sulfinpyrazone therapy." Arch Intern Med 136 (1976): 1060-1

4. Walls M, Goral S, Stone W "Acute renal failure due to sulfinpyrazone." Am J Med Sci 315 (1998): 319-21

5. Keidar S, Kohan R, Levy J, Grenadier E, Palant A, Ben Ari J "Non oliguric acute renal failure after treatment with sulfinpyrazone." Clin Nephrol 17 (1982): 266-7

6. Howard T, Hoy RH, Warren S, Georgiev M, Selinger H "Acute renal dysfunction due to sulfinpyrazone therapy in post- myocardial infarction cardiomegaly: reversible hypersensitiv interstitial nephritis." Am Heart J 102 (1981): 294-5

7. Lijnen P, Boelaert J, van Eeghem P, Daneels R, Schurgers M, de Jaegere P, van der Stichele E, Vincke J, Fagard R, Verschueren LJ, Amery A "Decrease in renal function due to sulphinpyrazone treatment early after myocardial infarction." Clin Nephrol 19 (1983): 143-6

8. Keidar S, Kohan R, Levy J, et al "Non oliguric acute renal failure after treatment with sulfinpyrazone." Clin Nephrol 17 (1982): 266-7

9. Lenfant F, Lahet JJ, Volot F, Schafer I, Freysz M, Rochette L "Effects of bupivacaine on human erythrocytes submitted to stress and evidence for an interaction between bupivacaine and flumazenil." Br J Clin Pharmacol 48 (1999): 826-8

10. Boelaert J, Lijnen P, Robbens E, Rocher A, Daneels R, Schurgers M, Amery A "Impairment of renal function due to sulphinpyrazone after coronary artery bypass surgery: a prospective double-blind study." J Cardiovasc Pharmacol 8 (1986): 386-91

Not all side effects for Anturane may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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