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Aloxi Side Effects

Generic Name: palonosetron

Note: This page contains information about the side effects of palonosetron. Some of the dosage forms included on this document may not apply to the brand name Aloxi.

For the Consumer

Applies to palonosetron: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by palonosetron (the active ingredient contained in Aloxi). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking palonosetron, check with your doctor or nurse immediately:

Less common:
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fainting
  • fever
  • irregular heartbeats that continue
  • sweating
  • unusual tiredness or weakness
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • extra heartbeats
  • nervousness
  • pain in the shoulders, arms, jaw, or neck
  • pounding in the ears
  • slow or fast heartbeat
Incidence not known:
  • Agitation
  • diarrhea
  • overactive reflexes
  • poor coordination
  • restlessness
  • shivering
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching

If any of the following symptoms of overdose occur while taking palonosetron, get emergency help immediately:

Symptoms of overdose:
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • collapse
  • gasping to breathe
  • paleness of the skin
  • seizures

Minor Side Effects

Some of the side effects that can occur with palonosetron may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Difficulty having a bowel movement (stool)
  • headache
Less common:
  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • blood in the urine
  • bloody or black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • chills
  • continuing ringing or buzzing
  • cough
  • decrease in frequency of urination
  • decrease in urine volume
  • deep breathing
  • difficulty in passing urine
  • drowsiness
  • dry mouth
  • excess air or gas in the stomach or intestines
  • excessive sleeping
  • eye irritation
  • fear
  • feeling happy
  • feeling of warmth
  • flushed dry skin
  • fruit-like breath odor
  • general feeling of discomfort or illness
  • hearing loss
  • heartburn
  • hiccups
  • impaired vision
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • joint pain
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle aches and pains
  • muscle tremors
  • numbness or tingling in the hands, feet, or lips
  • painful knees and ankles
  • painful urination
  • passing gas
  • raised red swellings on the skin, the buttocks, legs or ankles
  • rash
  • red, sore eyes
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sore throat
  • stomach discomfort, upset, or pain
  • sugar in the urine
  • swelling or protruding veins
  • trouble sleeping
  • unexplained noise in the ears
  • unexplained weight loss
  • unusually deep sleep
  • unusually long duration of sleep
  • vein discoloration
  • weakness or heaviness of the legs

For Healthcare Professionals

Applies to palonosetron: intravenous solution, oral capsule


Common (1% to 10%): Bradycardia, hypotension, nonsustained tachycardia
Uncommon (0.1% to 1%): Hypertension, myocardial ischemia, extrasystoles, sinus tachycardia, sinus arrhythmia, supraventricular extrasystoles, QT prolongation[Ref]


Uncommon (0.1% to 1%): Allergic dermatitis, rash[Ref]


Common (1% to 10%): Constipation, diarrhea
Uncommon (0.1% to 1%): Appetite decrease, dyspepsia, abdominal pain, dry mouth, hiccups, flatulence[Ref]


Uncommon (0.1% to 1%): Transient, asymptomatic increases in AST and/or ALT and bilirubin; increased transaminases[Ref]


Common (1% to 10%): Hyperkalemia
Uncommon (0.1% to 1%): Electrolyte fluctuations, hyperglycemia, metabolic acidosis, glycosuria[Ref]


Uncommon (0.1% to 1%): Urinary retention[Ref]


Common (1% to 10%): Anxiety
Uncommon (0.1% to 1%): Euphoric mood[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Fatigue, fever, hot flash, insomnia, somnolence, hypersomnia, paresthesia[Ref]


Common (1% to 10%): Weakness
Uncommon (0.1% to 1%): Arthralgia[Ref]


Uncommon (0.1% to 1%): Eye irritation, amblyopia[Ref]


Very rare (less than 0.01%): Injection site reactions (burning, induration, discomfort, and pain)[Ref]


Uncommon (0.1% to 1%): Motion sickness, tinnitus, vein discoloration, vein distention, influenza-like syndrome[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Aloxi (palonosetron)." MGI Pharma Inc, Minnetonka, MN.

4. Eisenberg P, Figueroa-Vadillo J, Zamora R, et al. "Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist." Cancer 98 (2003): 2473-82

Not all side effects for Aloxi may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.