Alinia Side Effects
Generic Name: nitazoxanide
Note: This page contains information about the side effects of nitazoxanide. Some of the dosage forms included on this document may not apply to the brand name Alinia.
For the Consumer
Applies to nitazoxanide: oral powder for suspension, oral tablet
In addition to its needed effects, some unwanted effects may be caused by nitazoxanide (the active ingredient contained in Alinia). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking nitazoxanide:Incidence not known:
Minor Side Effects
Some of the side effects that can occur with nitazoxanide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common:
- Abdominal or stomach pain
- urine changes
- hives or welts, itching, or skin rash
- redness of the skin
- trouble breathing
For Healthcare Professionals
Applies to nitazoxanide: oral powder for reconstitution, oral tablet
Gastrointestinal side effects have included abdominal pain (6.6% to 7.8%), diarrhea (2.1% to 4.2%), and nausea (3%). Side effects occurring in less than 1% of patients have included vomiting, anorexia, flatulence, dyspepsia, constipation, dry mouth, and thirst.[Ref]
The incidence of gastrointestinal side effects may be dose related. Abdominal pain, diarrhea and discolored urine occurred more often in subjects receiving higher doses (1 gram twice daily).[Ref]
Nervous system side effects have included headache (3.1%). Dizziness, somnolence, insomnia, tremor, and hypesthesia have been reported by less than 1% of the patients.[Ref]
Adverse effects affecting the body as a whole have included asthenia, fever, pain (pelvic/back), flu syndrome, ear ache, and chills in less than 1% of patients.[Ref]
Metabolic side effects have included increased creatinine and SGPT in less than 1% of patients.[Ref]
Dermatologic side effects have included pruritus, rash, and sweat in less than 1% of patients.[Ref]
Ocular side effects have included pale yellow eye discoloration (<1%).[Ref]
Respiratory side effects have included epistaxis, rhinitis, lung disease, and pharyngitis.[Ref]
Genitourinary side effects have included discolored urine, dysuria, amenorrhea, metrorrhagia, and edema labia.[Ref]
In general, side effects have been mild and transient in nature. The most frequent side effects have included abdominal pain, diarrhea, vomiting, and headache, and the rates of occurrence were not significantly different from placebo.[Ref]
Musculoskeletal side effects have included myalgia, leg cramps, and spontaneous bone fracture.[Ref]
Cardiovascular side effects have included tachycardia, syncope, and hypertension.[Ref]
Hematologic side effects have included anemia and leukocytosis.[Ref]
Renal side effects have included kidney pain.[Ref]
1. "Product Information. Alinia (nitazoxanide)." Romark Laboratories L.C., Tampa, FL.
2. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Clin Infect Dis 40 (2005): 1173-80
3. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." Int J Clin Pharmacol Ther 40 (2002): 221-7
Not all side effects for Alinia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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