Alinia Side Effects

Generic Name: nitazoxanide

Note: This page contains information about the side effects of nitazoxanide. Some of the dosage forms included on this document may not apply to the brand name Alinia.

For the Consumer

Applies to nitazoxanide: oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by nitazoxanide (the active ingredient contained in Alinia). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking nitazoxanide:

• Diarrhea

Minor Side Effects

Some of the side effects that can occur with nitazoxanide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Abdominal or stomach pain
• headache
• nausea
• urine changes

• Dizziness
• heartburn
• hives or welts, itching, or skin rash
• redness of the skin
• trouble breathing
• vomiting

For Healthcare Professionals

Applies to nitazoxanide: oral powder for reconstitution, oral tablet

Gastrointestinal

Gastrointestinal side effects have included abdominal pain (6.6% to 7.8%), diarrhea (2.1% to 4.2%), and nausea (3%). Side effects occurring in less than 1% of patients have included vomiting, anorexia, flatulence, dyspepsia, constipation, dry mouth, and thirst.^[Ref]

The incidence of gastrointestinal side effects may be dose related. Abdominal pain, diarrhea and discolored urine occurred more often in subjects receiving higher doses (1 gram twice daily).^[Ref]

Nervous system

Nervous system side effects have included headache (3.1%). Dizziness, somnolence, insomnia, tremor, and hypesthesia have been reported by less than 1% of the patients.^[Ref]

Other

Adverse effects affecting the body as a whole have included asthenia, fever, pain (pelvic/back), flu syndrome, ear ache, and chills in less than 1% of patients.^[Ref]

Metabolic

Metabolic side effects have included increased creatinine and SGPT in less than 1% of patients.^[Ref]

Dermatologic

Dermatologic side effects have included pruritus, rash, and sweat in less than 1% of patients.^[Ref]

Ocular

Ocular side effects have included pale yellow eye discoloration (<1%).^[Ref]

Respiratory

Respiratory side effects have included epistaxis, rhinitis, lung disease, and pharyngitis.^[Ref]

Genitourinary

Genitourinary side effects have included discolored urine, dysuria, amenorrhea, metrorrhagia, and edema labia.^[Ref]

General

In general, side effects have been mild and transient in nature. The most frequent side effects have included abdominal pain, diarrhea, vomiting, and headache, and the rates of occurrence were not significantly different from placebo.^[Ref]

Musculoskeletal

Musculoskeletal side effects have included myalgia, leg cramps, and spontaneous bone fracture.^[Ref]

Cardiovascular

Cardiovascular side effects have included tachycardia, syncope, and hypertension.^[Ref]

Hematologic

Hematologic side effects have included anemia and leukocytosis.^[Ref]

Renal

Renal side effects have included kidney pain.^[Ref]

Not all side effects for Alinia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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