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Alecensa Side Effects

Generic name: alectinib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jul 21, 2022.

Note: This document contains side effect information about alectinib. Some dosage forms listed on this page may not apply to the brand name Alecensa.

Applies to alectinib: oral capsule.

Serious side effects of Alecensa

Along with its needed effects, alectinib (the active ingredient contained in Alecensa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alectinib:

More common

Less common


Incidence not known

Other side effects of Alecensa

Some side effects of alectinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to alectinib: oral capsule.


Very common (10% or more): Anemia (62%), lymphopenia (14%), neutropenia (14%)

Postmarketing reports: Hemolytic anemia[Ref]


Very common (10% or more): Increased AST (51%), increased alkaline phosphatase (47%), hyperbilirubinemia (39%), increased ALT (34%)[Ref]


Very common (10% or more): Increased CPK (43%), myalgia/musculoskeletal pain (29%), back pain (12%), back pain (12%)[Ref]


Very common (10% or more): Fatigue/asthenia (26%), edema (e.g., peripheral edema, edema, eyelid edema, localized edema, face edema) (22%)[Ref]


Very common (10% or more): Hyperglycemia (36%), hypocalcemia (32%), hypokalemia (29%), hypophosphatemia (21%), hyponatremia (20%), increased weight (11%)[Ref]


Very common (10% or more): Constipation (34%), nausea (18%), diarrhea (16%), vomiting (12%)[Ref]


Very common (10% or more): Increased creatinine (e.g., increased blood creatinine, creatinine renal clearance decreased, glomerular filtration rate decreased, acute kidney injury) (28%)[Ref]


Very common (10% or more): Rash (e.g., acneiform dermatitis, erythema, and different types of rash [macular, papular, maculopapular, generalized, and pruritic]) (15%)

Common (1% to 10%): Photosensitivity[Ref]

Nervous system

Very common (10% or more): Headache (17%)

Common (1% to 10%): Dysgeusia/hypogeusia[Ref]


Very common (10% or more): Cough (19%), dyspnea (16%)

Uncommon (0.1% to 1%): Interstitial lung disease[Ref]


Very common (10% or more): Vision disorder (e.g., blurred vision, vitreous floaters, visual impairment, reduced visual acuity, asthenopia, diplopia) (10%)[Ref]


Very common (10% or more): Bradycardia (11%)[Ref]

Frequently asked questions


1. (2015) "Product Information. Alecensa (alectinib)." Genentech

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.