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Alecensa Side Effects

Generic name: alectinib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jul 21, 2022.

Note: This document contains side effect information about alectinib. Some of the dosage forms listed on this page may not apply to the brand name Alecensa.


Common side effects of Alecensa include: cough, dyspnea, increased creatine phosphokinase in blood specimen, increased serum aspartate aminotransferase, musculoskeletal pain, and myalgia. Other side effects include: bradycardia, and increased serum bilirubin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alectinib: oral capsules

Side effects include:

Fatigue, constipation, edema, myalgia, anemia.

For Healthcare Professionals

Applies to alectinib: oral capsule


Very common (10% or more): Anemia (62%), lymphopenia (14%), neutropenia (14%)

Postmarketing reports: Hemolytic anemia[Ref]


Very common (10% or more): Increased AST (51%), increased alkaline phosphatase (47%), hyperbilirubinemia (39%), increased ALT (34%)[Ref]


Very common (10% or more): Increased CPK (43%), myalgia/musculoskeletal pain (29%), back pain (12%), back pain (12%)[Ref]


Very common (10% or more): Fatigue/asthenia (26%), edema (e.g., peripheral edema, edema, eyelid edema, localized edema, face edema) (22%)[Ref]


Very common (10% or more): Hyperglycemia (36%), hypocalcemia (32%), hypokalemia (29%), hypophosphatemia (21%), hyponatremia (20%), increased weight (11%)[Ref]


Very common (10% or more): Constipation (34%), nausea (18%), diarrhea (16%), vomiting (12%)[Ref]


Very common (10% or more): Increased creatinine (e.g., increased blood creatinine, creatinine renal clearance decreased, glomerular filtration rate decreased, acute kidney injury) (28%)[Ref]


Very common (10% or more): Rash (e.g., acneiform dermatitis, erythema, and different types of rash [macular, papular, maculopapular, generalized, and pruritic]) (15%)

Common (1% to 10%): Photosensitivity[Ref]

Nervous system

Very common (10% or more): Headache (17%)

Common (1% to 10%): Dysgeusia/hypogeusia[Ref]


Very common (10% or more): Cough (19%), dyspnea (16%)

Uncommon (0.1% to 1%): Interstitial lung disease[Ref]


Very common (10% or more): Vision disorder (e.g., blurred vision, vitreous floaters, visual impairment, reduced visual acuity, asthenopia, diplopia) (10%)[Ref]


Very common (10% or more): Bradycardia (11%)[Ref]

Frequently asked questions


1. "Product Information. Alecensa (alectinib)." Genentech (2015):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.