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Alecensa

Pronunciation: a-le-sen-sah
Generic name: alectinib
Dosage form: oral capsules
Drug class: Multikinase inhibitors

Medically reviewed by Carmen Pope, BPharm. Last updated on Jul 2, 2024.

What is Alecensa?

Alecensa (alectinib) is an oral kinase inhibitor that may be used to treat certain types of non-small cell lung cancer (NSCLC) in adults that have been caused by an abnormal anaplastic lymphoma kinase (ALK) gene, specifically:

Alecensa is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene). Your doctor will test you for this gene.

Alecensa works by targeting ALK and RET -- these are 2 tyrosine kinases present in 5% to 7% of people with NSCLC. By preventing the activity of these kinases, Alecensa reduces the viability of cancer cells.

Alecensa was FDA approved on December 11, 2015.

Alecensa side effects

Common Alecensa side effects may include:

Serious side effects and warnings

Alecensa can cause serious or life-threatening side effects.

Get emergency medical help if you have signs of an allergic reaction to Alecensa, such as hives; difficulty breathing; or swelling of your face, lips, tongue, or throat.

Serious side effects of Alecensa include the following:

Liver problems (hepatotoxicity). These are common with Alecensa and can be severe. Your healthcare provider will do blood tests at least every 2 weeks for the first 3 months, and then 1 time each month and
as needed during treatment to check your liver function. Tell your healthcare provider right away if you get any of the following signs and symptoms:

Lung problems, which may be severe or life-threatening and similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening symptoms, including trouble breathing, shortness of breath, cough, or fever.

Kidney problems, which may be fatal. Tell your healthcare provider right away if you have a change in the amount or color of your urine, or if you get new or worsening swelling in your legs or feet.

Slow heartbeat (bradycardia). Alecensa may cause very slow heartbeats that can be severe. Your healthcare
provider will check your heart rate and blood pressure during treatment. Tell your healthcare
provider right away if you feel dizzy, lightheaded, or if you faint during treatment. Tell your
healthcare provider if you take any heart or blood pressure medicines.

Severe muscle pain, tenderness, and weakness (myalgia). Muscle problems are common with Alecensa and can be severe. Your healthcare provider will do blood tests at least every 2 weeks for the first month and as needed during treatment. Tell your healthcare provider right away if you get new or worsening signs and
symptoms of muscle problems, including unexplained muscle pain or muscle pain that does not go away,
tenderness, or weakness.

Breakdown of healthy red blood cells earlier than normal (hemolytic anemia). Hemolytic anemia can happen in some people who take Alecensa. If this happens, you may not have enough healthy red blood cells. Your
healthcare provider may temporarily stop treatment and do blood tests, if needed, to check for this problem. If you develop hemolytic anemia, your healthcare provider may either restart you at a lower dose when the
hemolytic anemia goes away or may stop your treatment. Tell your healthcare provider right away
if you experience yellow skin (jaundice), weakness or dizziness, or shortness of breath.

Call your doctor at once if you have:

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

It is not known if Alecensa is safe and effective in children.

Before taking this medicine

You should not use Alecensa if you are allergic to alectinib or any of the inactive ingredients in Alecensa.

Tell your doctor if you have ever had:

Tell your healthcare provider if you are pregnant, intending to become pregnant, or breastfeeding.

Pregnancy

Alecensa can harm an unborn baby or cause birth defects if the mother or the father is taking this medicine.

Breastfeeding

It is not known whether Alecensa passes into breast milk or if it could harm a nursing baby. You should not breastfeed while you are using alectinib and for at least 1 week after your last dose.

How should I take Alecensa?

Before you start treatment with Alecensa, your doctor will perform a special test to make sure Alecensa is the best treatment for your type of lung cancer. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

The usual dosage of Alecensa is 600 mg twice daily.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture, heat, and light.

Alecensa dosing

Usual Alecensa Adult Dose for Non-Small Cell Lung Cancer:

Duration of Therapy: Until disease progression or unacceptable toxicity

Comments: This drug should be taken with food.

Rybrevant, Opdivo, methotrexate, Keytruda, pembrolizumab, cisplatin, Avastin, Tagrisso

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. If you vomit shortly after taking Alecensa, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Alectinib could make you sunburn more easily. Avoid sunlight or tanning beds during treatment and for at least 7 days after your last dose of Alecensa. Wear protective clothing and use sunscreen (SPF 50 or higher) when you are outdoors.

What other drugs will affect Alecensa?

Other drugs may interact with alectinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does Alecensa interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Storage

Store at room temperature. Do not store at temperatures above 86°F (30°C). Keep in the original container, and keep dry and away from light.

Keep out of the reach of children.

Ingredients

Active ingredient: alectinib.

Inactive ingredients: lactose monohydrate, hydroxypropylcellulose, sodium lauryl sulfate, magnesium stearate, and carboxymethylcellulose calcium.

Capsule shell: hypromellose, carrageenan, potassium chloride, titanium dioxide, corn starch, and carnauba wax.

Printing ink: red iron oxide (E172), yellow iron oxide (E172), FD&C Blue No. 2 aluminum lake (E132), carnauba wax, white shellac, and glyceryl monooleate.

Available as Alecensa 150 mg capsules.

Who makes Alecensa?

Genentech, Inc. makes Alecensa.

Popular FAQ

Can you get an Alecensa free trial?

Yes, if you are waiting on an answer from your insurance company on coverage for Alecensa, you may be able to receive a 30-day Alecensa free trial if you are eligible. The SureStart Program from Genentech and your doctor can help you determine if you qualify. In addition, The Genentech Patient Foundation may be able to provide free Alecensa if you don't have insurance or have financial concerns and qualify. For assistance talk to your healthcare provider or call 1-877-436-3683.

Is Alecensa immunotherapy?

Alecensa is not an immunotherapy but a targeted drug used to treat non-small cell lung cancer (NSCLC) with ALK+ gene mutations. It is classified as a tyrosine kinase inhibitor and kills cancer cells by targeting a specific area in the cell that leads to the cancer. Immunotherapies, for example Opdivo or Keytruda, work by helping your own immune system to fight cancer.

Is Alecensa a form of chemotherapy?

Alecensa is not considered a traditional form of chemotherapy, but is a targeted drug used to treat non-small cell lung cancer with ALK+ mutations. ALK gene changes lead to the growth and spread of cancer cells. Alecensa (alectinib) is given as an oral capsule you can take at home. It might be given instead of chemo in people whose cancers have an ALK gene rearrangement.

What is the mechanism of action for Alecensa (alectinib)?

Alecensa (alectinib) is a tyrosine kinase inhibitor (TKI) that works specifically on a protein called anaplastic lymphoma kinase (ALK protein). Tyrosine kinases (TK) help to determine processes such as growth, differentiation, metabolism, and cell death, and are involved in signaling pathways – these are pathways that control and regulate the flow of information between cells and their outside environment. Research has linked abnormal TK activity or mutations to various cancers – one of these is non-small cell lung cancer. Anaplastic lymphoma kinase (ALK) mutations are present in approximately 5% of NSCLC cases, and by inhibiting this protein, Alecensa reduces the growth of ALK-positive metastatic NSCLC. Alecensa is only used in metastatic NSCLC that has been tested and confirmed to be ALK-positive. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.